Evidence map›Paper›PMID 37241793›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthesis and Antiproliferative Insights of Lipophilic Ru(II)-Hydroxy Stearic Acid Hybrid Species.

Giacomo Drius, Silvia Bordoni, Carla Boga, Magda Monari, Jessica Fiori, Erika Esposito, Chiara Zalambani, Luca Pincigher, Giovanna Farruggia, Natalia Calonghi and 1 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giacomo DriusDepartment of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0009-0005-2637-1920
Silvia BordoniDepartment of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0002-2338-7557
Carla BogaDepartment of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0003-2851-8939
Magda MonariDepartment of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0003-2766-7625
Jessica FioriDepartment of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-6004-5118
Erika EspositoDepartment of Chemistry "Giacomo Ciamician", University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0009-0000-4901-7960
Chiara ZalambaniDepartment of Pharmacy and Biotechnology, University of Bologna, Via San Donato 15, 40127 Bologna, Italy.ORCID 0009-0008-4325-4322
Luca PincigherDepartment of Pharmacy and Biotechnology, University of Bologna, Via San Donato 15, 40127 Bologna, Italy.ORCID 0009-0002-9806-2789
Giovanna FarruggiaDepartment of Pharmacy and Biotechnology, University of Bologna, Via San Donato 15, 40127 Bologna, Italy.ORCID 0000-0003-3599-7034
Natalia CalonghiDepartment of Pharmacy and Biotechnology, University of Bologna, Via San Donato 15, 40127 Bologna, Italy.ORCID 0000-0002-9715-6890
Gabriele MichelettiDepartment of Industrial Chemistry 'Toso Montanari', Alma Mater Studiorum, Università di Bologna, Viale del Risorgimento 4, 40136 Bologna, Italy.ORCID 0000-0001-9746-2356

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metallodrugs represent a combination of multifunctionalities that are present concomitantly and can act differently on diverse biotargets. Their efficacy is often related to the lipophilic features exhibited both by long carbo-chains and the phosphine ligands. Three Ru(II) complexes containing hydroxy stearic acids (HSAs) were successfully synthesized in order to evaluate possible synergistic effects between the known antitumor activity of HSA bio-ligands and the metal center. HSAs were reacted with [Ru(H)

Indexed as

Antineoplastic AgentsCoordination ComplexesRutheniumCell Line, TumorCell ProliferationHeLa CellsHumansLigandsAntineoplastic AgentsCoordination ComplexesLigandsRutheniumalkyl chainanticancerDNA damagehydroxy stearic acidlipophilicityRu(II)

Identifiers

PMID37241793
PMCPMC10222286

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.