Evidence map›Paper›PMID 37241787›Full record

ArticleMolecules (Basel, Switzerland)2023

Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery.

Yixiang Wang, Xiao Si, Yi Feng, Dan Feng, Xiaoyu Xu, Yan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yixiang WangSchool of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China.
Xiao SiSchool of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China.
Yi FengSchool of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China.
Dan FengNanjing Vazyme Biotechnology Company, Nanjing 210034, China.
Xiaoyu XuNanjing Vazyme Biotechnology Company, Nanjing 210034, China.
Yan ZhangSchool of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Analytical Chemistry for Life Sciences, Nanjing University, Nanjing 210023, China.ORCID 0000-0002-8858-8894

Funding

Natural Science Foundation of Jiangsu Province BK20202004, BE2022835
6 · The paper itself

Abstract

Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy. The screening of ionizable lipid libraries with common features but diverse structures holds the promise of finding new candidates for LNPs to deliver different nucleic acid drugs such as messenger RNAs (mRNAs). Chemical strategies for the facile construction of ionizable lipid libraries with diverse structure are in high demand. Here, we report on the ionizable lipids containing the triazole moiety prepared by the copper-catalyzed alkyne-azide click reaction (CuAAC). We demonstrated that these lipids served well as the major component of LNPs, in order to encapsulate mRNA using luciferase mRNA as the model system. Thus, this study shows the potential of click chemistry in the preparation of lipid libraries for LNP assembly and mRNA delivery.

Indexed as

LipidsNanoparticlesGenetic TherapyRNA, MessengerRNA, Small InterferingLipidsRNA, MessengerRNA, Small Interferingclick reactionionizable lipidslipid nanoparticlesmRNA delivery

Identifiers

PMID37241787
PMCPMC10223118

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.