Evidence map›Paper›PMID 37241553›Full record

ArticleMicromachines2023

A User-Centric 3D-Printed Modular Peristaltic Pump for Microfluidic Perfusion Applications.

Jorge A Cataño, Steven Farthing, Zeus Mascarenhas, Nathaniel Lake, Prasad K D V Yarlagadda, Zhiyong Li, Yi-Chin Toh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Micromachines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jorge A CatañoSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.
Steven FarthingSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.
Zeus MascarenhasSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.ORCID 0000-0002-8131-2502
Nathaniel LakeSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.ORCID 0009-0004-0879-9256
Prasad K D V YarlagaddaSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.ORCID 0000-0002-7026-4795
Zhiyong LiSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.
Yi-Chin TohSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane 4000, Australia.
Queensland University of Technology · AU

Funding

Australian Research Council DP200101658Australian Research Council DP200103942Australian Research Council FT180100157
6 · The paper itself

Abstract

Microfluidic organ-on-a-chip (OoC) technology has enabled studies on dynamic physiological conditions as well as being deployed in drug testing applications. A microfluidic pump is an essential component to perform perfusion cell culture in OoC devices. However, it is challenging to have a single pump that can fulfil both the customization function needed to mimic a myriad of physiological flow rates and profiles found in vivo and multiplexing requirements (i.e., low cost, small footprint) for drug testing operations. The advent of 3D printing technology and open-source programmable electronic controllers presents an opportunity to democratize the fabrication of mini-peristaltic pumps suitable for microfluidic applications at a fraction of the cost of commercial microfluidic pumps. However, existing 3D-printed peristaltic pumps have mainly focused on demonstrating the feasibility of using 3D printing to fabricate the structural components of the pump and neglected user experience and customization capability. Here, we present a user-centric programmable 3D-printed mini-peristaltic pump with a compact design and low manufacturing cost (~USD 175) suitable for perfusion OoC culture applications. The pump consists of a user-friendly, wired electronic module that controls the operation of a peristaltic pump module. The peristaltic pump module comprises an air-sealed stepper motor connected to a 3D-printed peristaltic assembly, which can withstand the high-humidity environment of a cell culture incubator. We demonstrated that this pump allows users to either program the electronic module or use different-sized tubing to deliver a wide range of flow rates and flow profiles. The pump also has multiplexing capability as it can accommodate multiple tubing. The performance and user-friendliness of this low-cost, compact pump can be easily deployed for various OoC applications.

Indexed as

3D printingmicrofluidic perfusionmodularperistaltic pump

Identifiers

PMID37241553
PMCPMC10222968
OpenAlexW4367052656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.