Evidence map›Paper›PMID 37241009›Full record

ReviewJournal of personalized medicine2023

Clinical Application of Circular RNAs as Biomarkers in Acute Ischemic Stroke.

Chiara Siracusa, Niccolò Vono, Maria Benedetta Morano, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Eleonora Cianflone, Marek Postula, Daniele Torella, Salvatore De Rosa

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiara SiracusaDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Niccolò VonoDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-1759-0313
Maria Benedetta MoranoDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Jolanda SabatinoDepartment of Children and Woman's Health, University of Padua, 35121 Padua, Italy.ORCID 0000-0002-1661-5419
Isabella LeoRoyal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London SW3 5NP, UK.ORCID 0000-0002-4774-0888
Ceren EyiletenCentre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-3324-9625
Eleonora CianfloneDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-1675-2093
Marek PostulaCentre for Preclinical Research and Technology, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-7826-4458
Daniele TorellaDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0002-4915-5084
Salvatore De RosaDepartment of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.ORCID 0000-0001-5388-942X

Funding

National Science Center 2018/31/B/NZ7/01137
6 · The paper itself

Abstract

Despite the substantial improvement in diagnosis and treatment within the last decades, ischemic stroke still represents a challenge, responsible still for a high burden of morbidity and mortality. Among the unmet clinical needs are the difficulties in identifying those subjects with the greatest risk of developing a stroke, the challenges in obtaining a timely diagnosis, the prompt recognition of the different clinical forms of stroke, the assessment of the response to treatments and the prognostic assessment. All these issues might be improved with appropriate smart biomarkers that could better inform clinical management. The present article offers an overview of the potential role of circular RNAs as disease biomarkers in stroke. A systematic approach was adopted to gather all potentially relevant information in order to provide a panoramic view on this class of promising molecules.

Indexed as

biomarkerscerebrovascular diseasecircRNAsischemianoncoding RNAsstroke

Identifiers

PMID37241009
PMCPMC10221059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.