Evidence map›Paper›PMID 37240895›Full record

ReviewJournal of personalized medicine2023

Precision Medicine in Oral Health and Diseases: A Systematic Review.

Giuseppina Malcangi, Assunta Patano, Mariafrancesca Guglielmo, Roberta Sardano, Giulia Palmieri, Chiara Di Pede, Elisabetta de Ruvo, Alessio Danilo Inchingolo, Antonio Mancini, Francesco Inchingolo and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  7. Transcription-based comparison ofMicrobiology spectrum · 2026
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  17. Engineered Tissue Models to Decode Host-Microbiota Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Giuseppina MalcangiDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0001-9745-7506
Assunta PatanoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0001-7395-3126
Mariafrancesca GuglielmoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-2792-7167
Roberta SardanoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Giulia PalmieriDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-0292-1965
Chiara Di PedeDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Elisabetta de RuvoDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Alessio Danilo InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-6366-1039
Antonio ManciniDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-7103-4086
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-3797-5883
Ioana Roxana BordeaDepartment of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0001-7166-9949
Gianna DipalmaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-5947-8987
Angelo Michele InchingoloDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0003-0104-6337
University of Bari Aldo Moro · ITIuliu Hațieganu University of Medicine and Pharmacy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine (PM) is personalized medicine that can develop targeted medical therapies for the individual patient, in which "omics" sciences lead to an integration of data that leads to highly predictive models of the functioning of the individual biological system. They enable rapid diagnosis, assessment of disease dynamics, identification of targeted treatment protocols, and reduction of costs and psychological stress. "Precision dentistry" (DP) is one promising application that need further investigation; the purpose of this paper is therefore to give physicians an overview of the knowledge they need to enhance treatment planning and patient response to therapy. A systematic literature review was conducted on the PubMed, Scopus, and Web of Science databases by analyzing the articles examining the role of precision medicine in dentistry. PM aims to shed light on cancer prevention strategies, by identifying risk factors, and on malformations such as orofacial cleft. Another application is pain management by repurposing drugs created for other diseases to target biochemical mechanisms. The significant heritability of traits regulating bacterial colonization and local inflammatory responses is another result of genomic research, and is useful for DP in the field of caries and periodontitis. This approach may also be useful in the field of orthodontics and regenerative dentistry. The possibility of creating an international network of databases will lead to the diagnosis, prediction, and prevention of disease outbreaks, providing significant economic savings for the world's health care systems.

Indexed as

dentistrygenomicsmetabolomicoral diseasesoral healthprecision medicine

Identifiers

PMID37240895
PMCPMC10219503
OpenAlexW4366987068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.