Evidence map›Paper›PMID 37240890›Full record

ArticleJournal of personalized medicine2023

Baseline Variability Affects N-of-1 Intervention Effect: Simulation and Field Studies.

Makoto Suzuki, Satoshi Tanaka, Kazuo Saito, Kilchoon Cho, Naoki Iso, Takuhiro Okabe, Takako Suzuki, Junichi Yamamoto

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Makoto SuzukiFaculty of Health Sciences, Tokyo Kasei University, 2-15-1 Inariyama, Sayama City 350-1398, Japan.
Satoshi TanakaLaboratory of Psychology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City 431-3192, Japan.ORCID 0000-0002-6525-682X
Kazuo SaitoFaculty of Health Sciences, Tokyo Kasei University, 2-15-1 Inariyama, Sayama City 350-1398, Japan.ORCID 0000-0001-7026-5395
Kilchoon ChoFaculty of Health Sciences, Tokyo Kasei University, 2-15-1 Inariyama, Sayama City 350-1398, Japan.
Naoki IsoFaculty of Health Sciences, Tokyo Kasei University, 2-15-1 Inariyama, Sayama City 350-1398, Japan.
Takuhiro OkabeFaculty of Health Sciences, Tokyo Kasei University, 2-15-1 Inariyama, Sayama City 350-1398, Japan.ORCID 0000-0003-3360-5068
Takako SuzukiSchool of Health Sciences, Saitama Prefectural University, 820 Sannomiya, Koshigaya City 343-8540, Japan.
Junichi YamamotoFaculty of Systems Design, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji City 192-0397, Japan.

Funding

Japan Science and Technology Agency [Moonshot R&D] [Grant Number JPMJMS2034-15]Japan Society for the Promotion of Science KAKENHI 18H03133
6 · The paper itself

Abstract

The simulation study investigated the relationship between the local linear trend model's data-comparison accuracy, baseline-data variability, and changes in level and slope after introducing the N-of-1 intervention. Contour maps were constructed, which included baseline-data variability, change in level or slope, and percentage of non-overlapping data between the state and forecast values by the local linear trend model. Simulation results showed that baseline-data variability and changes in level and slope after intervention affect the data-comparison accuracy based on the local linear trend model. The field study investigated the intervention effects for actual field data using the local linear trend model, which confirmed 100% effectiveness of previous N-of-1 studies. These results imply that baseline-data variability affects the data-comparison accuracy using a local linear trend model, which could accurately predict the intervention effects. The local linear trend model may help assess the intervention effects of effective personalized interventions in precision rehabilitation.

Indexed as

baseline-data variabilityintervention effectlocal linear trend modelN-of-1 trialprecision rehabilitation

Identifiers

PMID37240890
PMCPMC10219212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.