ArticleLife (Basel, Switzerland)2023
Prebiotic Synthesis of Aspartate Using Life's Metabolism as a Guide.
Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The emergence of metabolisms through Earth history and implications for biospheric evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Conversion of pyridoxal to pyridoxamine with NHThe FEBS journal · 2025Article
- Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth.PLoS biology · 2025Article
- Nonenzymatic Hydration of Phosphoenolpyruvate: General Conditions for Hydration in Protometabolism by Searching Across Pathways.Angewandte Chemie (International ed. in English) · 2025Article
- Pinpointing Conditions for a Metabolic Origin of Life: Underlying Mechanisms and the Role of Coenzymes.Accounts of chemical research · 2024Article
- Aspartate aminotransferase ofMicrobiology (Reading, England) · 2024Article
- Self-generating autocatalytic networks: structural results, algorithms and their relevance to early biochemistry.Journal of the Royal Society, Interface · 2024Article
- Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life.Frontiers in microbiology · 2023Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A protometabolic approach to the origins of life assumes that the conserved biochemistry of metabolism has direct continuity with prebiotic chemistry. One of the most important amino acids in modern biology is aspartic acid, serving as a nodal metabolite for the synthesis of many other essential biomolecules. Aspartate's prebiotic synthesis is complicated by the instability of its precursor, oxaloacetate. In this paper, we show that the use of the biologically relevant cofactor pyridoxamine, supported by metal ion catalysis, is sufficiently fast to offset oxaloacetate's degradation. Cu
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