ArticleJournal of clinical medicine2023
Association between Triglyceride-Glucose Index and Early Neurological Outcomes after Thrombolysis in Patients with Acute Ischemic Stroke.
Article in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The triglyceride-glucose index as a biomarker of diabetic retinopathy: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Prognostic value of the triglyceride-glucose index in patients with acute ischemic stroke undergoing endovascular treatment.The Journal of international medical research · 2026Article
- Effect of TyG index on endovascular therapy in large vessel occlusion stroke with different etiologies.BMC neurology · 2026Article
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
- A Review of Emerging Biomarkers Connecting Diabetes and Ischemic Stroke: Implications for Early Detection and Risk Stratification.Journal of diabetes research · 2026Review
- Association of higher triglyceride glucose index and triglyceride to high density lipoprotein cholesterol ratio with early-onset post-stroke depression.Scientific reports · 2025Article
- Can the triglyceride-glucose index predict stroke outcomes? A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Association between triglyceride-glucose index and risk of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage.Acta neurochirurgica · 2025Article
- Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke.Cardiovascular diabetology · 2025Article
- Effect of Insulin Resistance on Prognosis of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with or Without Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Triglyceride-glucose index as a biomarker to differentiate stroke etiologic subtypes: a hospital-based cross-sectional study.Biomarkers in medicine · 2025Article
- Analyzing the correlation between acute ischemic stroke and triglyceride-glucose index based on ordered logistic regression.Frontiers in neurology · 2025Article
- A Nomogram Incorporating Intracranial Atherosclerosis Score for Predicting Early Neurological Deterioration in Minor Stroke Patients With Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Association between the atherogenic index of plasma and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with early neurological deterioration after thrombolysis.Frontiers in neurology · 2025Article
- Nomogram Models Integrating TyG Index for Predicting Early Neurological Deterioration and 90-Day Outcomes in AIS Patients Undergoing IVT.Journal of central nervous system disease · 2025Article
- The predictive value of triglyceride-glucose index on early neurological functional improvement in non-diabetic patients with acute ischemic stroke undergoing intravenous thrombolysis.Frontiers in neurology · 2025Article
- Relationship between all-cause mortality and triglyceride-glucose-body mass index in elderly patients with intravenous thrombolysis for acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2025Article
- Association of the Triglyceride Glucose Index With Outcomes in Acute Ischemic Stroke Injury.Cureus · 2024Article
- Influence of TyG Index on Large Vascular Occlusive Stroke Following Endovascular Treatment.CNS neuroscience & therapeutics · 2024Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe triglyceride-glucose (TyG) index is a novel biomarker of insulin resistance which might plausibly influence endogenous fibrinolysis and thus early neurological outcomes in patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis using recombinant tissue-plasminogen activator.
methodsWe included consecutive AIS patients within 4.5 h of symptom onset undergoing intravenous thrombolysis between January 2015 and June 2022 in this multi-center retrospective observational study. Our primary outcome was early neurological deterioration (END), defined as ≥2 (END
resultsA total of 676 patients with AIS were evaluated. The median age was 68 (Interquartile range, IQR (60-76) years old), and 432 (63.9%) were males. A total of 89 (13.2%) patients developed END
conclusionsIncreasing TyG index was associated with a higher risk of END and a lower probability of ENI in patients with acute ischemic stroke treated with intravenous thrombolysis.
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Registered trials
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