Evidence map›Paper›PMID 37240547›Full record

ReviewJournal of clinical medicine2023

Management of the Sickle Cell Trait: An Opinion by Expert Panel Members.

Valeria Maria Pinto, Lucia De Franceschi, Barbara Gianesin, Antonia Gigante, Giovanna Graziadei, Letizia Lombardini, Giovanni Palazzi, Alessandra Quota, Rodolfo Russo, Laura Sainati and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  5. Article
  6. International flight-associated splenic infarction in a 33-year-old man with sickle cell trait.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  7. Whole Blood Transcriptomic Analysis of Sickle Cell Trait.European journal of haematology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Pipeline embolization in patients with hemoglobinopathies: A cohort study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Valeria Maria PintoCentro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, E.O. Ospedali Galliera, 16128 Genova, Italy.ORCID 0000-0002-8375-6289
Lucia De FranceschiDipartimento di Medicina AOUI, Università di Verona, 37124 Verona, Italy.ORCID 0000-0001-7093-777X
Barbara GianesinCentro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, E.O. Ospedali Galliera, 16128 Genova, Italy.
Antonia GiganteForAnemia Foundation, 16124 Genova, Italy.
Giovanna GraziadeiCentro Malattie Rare Internistiche, Medicina Generale, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.ORCID 0000-0002-6801-5730
Letizia LombardiniCentro Nazionale Trapianti, Istituto Superiore di Sanità, 00161 Roma, Italy.
Giovanni PalazziU.O. Oncoematologia Pediatrica, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.
Alessandra QuotaUOSD Talassemia, P.O. Vittorio Emanuele, 93012 Gela, Italy.
Rodolfo RussoClinica Nefrologica, Dialisi e Trapianto, Dipartimento di Medicina Integrata con il Territorio, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Laura SainatiOncoematologia Pediatrica, Azienda Ospedaliera-Università di Padova, 35128 Padova, Italy.
Donatella VenturelliServizio Immunotrasfusionale, Azienda Ospedaliero-Universitaria di Modena, 41125 Modena, Italy.
Gian Luca ForniCentro della Microcitemia, Anemie Congenite e Dismetabolismo del Ferro, E.O. Ospedali Galliera, 16128 Genova, Italy.ORCID 0000-0001-9833-1016
Raffaella OrigaTalassemia, Ospedale Pediatrico Microcitemico 'A.Cao', ASL8, Università di Cagliari, 09121 Cagliari, Italy.ORCID 0000-0002-2346-9616
Ente Ospedaliero Ospedali Galliera · ITAzienda Ospedaliero-Universitaria di Modena · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITIstituto Superiore di Sanità · ITOspedale Microcitemico · ITOspedale Policlinico San Martino · ITUniversity of Padua · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of individuals with the sickle cell trait exceeds 300 million worldwide, making sickle cell disease one of the most common monogenetic diseases globally. Because of the high frequency of sickle cell disease, reproductive counseling is of crucial importance. In addition, unlike other carrier states, Sickle Cell Trait (SCT) seems to be a risk factor for several clinical complications, such as extreme exertional injury, chronic kidney disease, and complications during pregnancy and surgery. This expert panel believes that increasing knowledge about these clinical manifestations and their prevention and management can be a useful tool for all healthcare providers involved in this issue.

Indexed as

exertional rhabdomyolysishemoglobinopathieskidney diseasepainpregnancysickle cell traitspecialist advicespleen infarctionsurgerytransplantation

Identifiers

PMID37240547
PMCPMC10219090
OpenAlexW4378516283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.