Evidence map›Paper›PMID 37240451›Full record

ArticleInternational journal of molecular sciences2023

Potential Binding Sites of Pharmacological Chaperone NCGC00241607 on Mutant β-Glucocerebrosidase and Its Efficacy on Patient-Derived Cell Cultures in Gaucher and Parkinson's Disease.

Alena E Kopytova, George N Rychkov, Alexander A Cheblokov, Elena V Grigor'eva, Mikhail A Nikolaev, Elena S Yarkova, Diana A Sorogina, Farid M Ibatullin, Galina V Baydakova, Artem D Izyumchenko and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Alena E KopytovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.ORCID 0000-0002-6557-0253
George N RychkovPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.ORCID 0000-0003-2767-9175
Alexander A CheblokovPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
Elena V Grigor'evaInstitute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Mikhail A NikolaevPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.ORCID 0000-0002-1952-4678
Elena S YarkovaInstitute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Diana A SoroginaInstitute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.
Farid M IbatullinPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
Galina V BaydakovaResearch Centre for Medical Genetics, Moscow 115522, Russia.
Artem D IzyumchenkoPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.ORCID 0000-0003-2919-1878
Daria A BogdanovaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
Vitali M BoitsovLaboratory of Nanobiotechnology, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, Saint-Petersburg 194021, Russia.ORCID 0000-0002-4857-2046
Akim V RybakovN.P. Bechtereva Institute of the Human Brain RAS, Saint-Petersburg 197376, Russia.
Irina V MiliukhinaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
Vadim A BezrukikhAlmazov National Medical Research Centre, Saint-Petersburg 197341, Russia.
Galina N SalogubAlmazov National Medical Research Centre, Saint-Petersburg 197341, Russia.
Ekaterina Y ZakharovaResearch Centre for Medical Genetics, Moscow 115522, Russia.
Sofya N PchelinaPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
Anton K EmelyanovPetersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Center «Kurchatov Institute», Gatchina 188300, Russia.
First Pavlov State Medical University of St. Petersburg · RUInstitute of Cytology and Genetics · RUPetersburg Nuclear Physics Institute · RUFederal Almazov North-West Medical Research Centre · RUInstitute of the Human Brain · RUResearch Centre for Medical Genetics · RUPeter the Great St. Petersburg Polytechnic University · RUSaint Petersburg Academic University · RU

Funding

Russian Science Foundation 22-25-00721
6 · The paper itself

Abstract

Mutations in the

Indexed as

Gaucher DiseaseParkinson DiseaseAcetanilidesBenzamidesBinding SitesCell Culture TechniquesGlucosylceramidaseGlycolipidsHumansMolecular Docking SimulationMutationAcetanilidesBenzamidesGlucosylceramidaseGlycolipidsNCGC607allosteric binding sitebinding free energyGaucher diseaseglucocerebrosidaseiPSC-derived dopaminergic neuronsnon-inhibitory chaperonesParkinson’s diseasepharmacological chaperones

Identifiers

PMID37240451
PMCPMC10219579
OpenAlexW4378087322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.