Evidence map›Paper›PMID 37240450›Full record

ArticleInternational journal of molecular sciences2023

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis-Pyrazoline Derivatives as Dual EGFR/BRAF

Lamya H Al-Wahaibi, Hesham A Abou-Zied, Eman A M Beshr, Bahaa G M Youssif, Alaa M Hayallah, Mohamed Abdel-Aziz

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  12. Recent Advances: Heterocycles in Drugs and Drug Discovery.International journal of molecular sciences · 2024
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  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lamya H Al-WahaibiDepartment of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11564, Saudi Arabia.
Hesham A Abou-ZiedMedicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.ORCID 0000-0001-6993-3325
Eman A M BeshrMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Bahaa G M YoussifPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Alaa M HayallahPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.ORCID 0000-0001-9517-8650
Mohamed Abdel-AzizMedicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.

Funding

Princess Nourah bint Abdulrahman University PNURSP2023R3
6 · The paper itself

Abstract

Some new Bis-pyrazoline hybrids

Indexed as

Antineoplastic AgentsCell ProliferationDensity Functional TheoryDrug DesignErbB ReceptorsProto-Oncogene Proteins B-rafPyrazolesApoptosisbcl-2-Associated X ProteinCaspase 3Caspase 8Cell LineCell SurvivalHumansMolecular Docking SimulationProto-Oncogene Proteins c-bcl-2Antineoplastic AgentsBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanBRAF protein, humanCASP3 protein, humanCASP8 protein, humanCaspase 3Caspase 8EGFR protein, humanErbB ReceptorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-bcl-2PyrazolesADMEantiproliferativeapoptosisDFThybridspyrazoline

Identifiers

PMID37240450
PMCPMC10218941

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.