Evidence map›Paper›PMID 37240349›Full record

ArticleInternational journal of molecular sciences2023

Transcriptome Profiling of Circulating Tumor Cells to Predict Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer.

Levi Groen, Iris Kloots, David Englert, Kelly Seto, Lana Estafanos, Paul Smith, Gerald W Verhaegh, Niven Mehra, Jack A Schalken

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Variable cellular and radiobiological effects of [Journal of experimental & clinical cancer research : CR · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Levi GroenDepartment of Urology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Iris KlootsDepartment of Medical Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0001-9181-1359
David EnglertANGLE Biosciences Inc., Toronto, ON M9W 1B3, Canada.ORCID 0000-0002-9506-6840
Kelly SetoANGLE Biosciences Inc., Toronto, ON M9W 1B3, Canada.
Lana EstafanosANGLE Biosciences Inc., Toronto, ON M9W 1B3, Canada.
Paul SmithANGLE Biosciences Inc., Toronto, ON M9W 1B3, Canada.
Gerald W VerhaeghDepartment of Urology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-0227-2280
Niven MehraDepartment of Medical Oncology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-4794-1831
Jack A SchalkenDepartment of Urology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

MDxHealth (Netherlands) NA
6 · The paper itself

Abstract

The clinical utility of circulating tumor cells (CTC) as a non-invasive multipurpose biomarker is broadly recognized. The earliest methods for enriching CTCs from whole blood rely on antibody-based positive selection. The prognostic utility of CTC enumeration using positive selection with the FDA-approved CellSearch

Indexed as

Neoplastic Cells, CirculatingProstatic Neoplasms, Castration-ResistantBiomarkers, TumorGene Expression ProfilingHumansMaleBiomarkers, Tumorandrogen receptor signaling inhibitorsbiomarkerscastration resistant prostate cancerchemotherapycirculating tumor cellsliquid biopsypredictiveprognosticprostate cancertranscriptomics

Identifiers

PMID37240349
PMCPMC10218842
OpenAlexW4377138379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.