Evidence map›Paper›PMID 37240280›Full record

ReviewInternational journal of molecular sciences2023

Early Clinical Outcomes of the First Commercialized Human Autologous Ex Vivo Cultivated Oral Mucosal Epithelial Cell Transplantation for Limbal Stem Cell Deficiency: Two Case Reports and Literature Review.

Hiroshi Toshida, Tomoto Kasahara, Masamichi Kiriyama, Yuma Iwasaki, Jobu Sugita, Kohei Ichikawa, Toshihiko Ohta, Katsumi Miyahara

Open access · goldAbstract readReviewCase Reports
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hiroshi ToshidaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.ORCID 0000-0003-4260-6687
Tomoto KasaharaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Masamichi KiriyamaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Yuma IwasakiDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Jobu SugitaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Kohei IchikawaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Toshihiko OhtaDepartment of Ophthalmology, Juntendo University Shizuoka Hospital, Shizuoka 410-2211, Japan.
Katsumi MiyaharaLaboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo 113-0033, Japan.
Juntendo University Shizuoka Hospital · JPJuntendo University · JP

Funding

Promotion and Mutual Aid Corporation for Private Schools of Japan none
6 · The paper itself

Abstract

The first product in the world for ex vivo cultivated oral mucosal epithelial cell transplantation (COMET) to treat limbal stem cell deficiency (LSCD), named Ocural

Indexed as

Corneal DiseasesMouth MucosaCells, CulturedCell TransplantationEpithelial CellsHumansLimbal Stem CellsStem Cell TransplantationTransplantation, AutologousCOMETcultivated oral mucosal epithelial cell transplantationlimbal stem cell deficiencyOcural®regeneration therapystem cell

Identifiers

PMID37240280
PMCPMC10219018
OpenAlexW4377211784

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.