Evidence map›Paper›PMID 37240278›Full record

ArticleInternational journal of molecular sciences2023

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma.

Ana Dunatov Huljev, Nela Kelam, Benjamin Benzon, Violeta Šoljić, Natalija Filipović, Valdi Pešutić Pisac, Merica Glavina Durdov, Katarina Vukojević

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ana Dunatov HuljevDepartment of Pathology, Forensic Medicine and Cytology, University Hospital of Split, 21000 Split, Croatia.
Nela KelamDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-6529-5474
Benjamin BenzonDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0003-3681-8499
Violeta ŠoljićDepartment of Anatomy, Histology and Embryology, School of Medicine, University of Mostar, 88000 Mostar, Bosnia and Herzegovina.
Natalija FilipovićDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0002-8943-4109
Valdi Pešutić PisacDepartment of Pathology, Forensic Medicine and Cytology, University Hospital of Split, 21000 Split, Croatia.
Merica Glavina DurdovDepartment of Pathology, Forensic Medicine and Cytology, University Hospital of Split, 21000 Split, Croatia.ORCID 0000-0002-8292-9854
Katarina VukojevićDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia.ORCID 0000-0003-2182-2890
University of Split · HRUniversity of Mostar · BA

Funding

Croatian Science Foundation grant no. IP-06-2016-2575
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) is the deadliest neoplasm of the urinary tract, and we are still far from completely understanding ccRCC development and treatment. The renal tissue paraffin blocks (20) of patients with ccRCC were collected at the University Hospital in Split from 2019 to 2020, and tissue sections were stained with patched (PTCH), anti-smoothened (SMO) and anti-Sonic Hedgehog (SHH) antibodies. SHH was highly expressed (31.9%) in grade 1 tumour, it being higher than all other grades and the control (

Indexed as

CarcinomaCarcinoma, Renal CellKidney NeoplasmsHedgehog ProteinsHumansPatched ReceptorsReceptors, Cell SurfaceReceptors, G-Protein-CoupledSignal TransductionSmoothened ReceptorHedgehog ProteinsPatched ReceptorsReceptors, Cell SurfaceReceptors, G-Protein-CoupledSmoothened Receptorpatchedrenal cell carcinomasmoothenedSonic Hedgehog

Identifiers

PMID37240278
PMCPMC10219518
OpenAlexW4377103384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.