Evidence map›Paper›PMID 37240246›Full record

ArticleInternational journal of molecular sciences2023

Human Umbilical Cord Mesenchymal Stem Cells Protect against Renal Ischemia-Reperfusion Injury by Secreting Extracellular Vesicles Loaded with miR-148b-3p That Target Pyruvate Dehydrogenase Kinase 4 to Inhibit Endoplasmic Reticulum Stress at the Reperfusion Stages.

Wei Shi, Xiang Zhou, Xinyuan Li, Xiang Peng, Guo Chen, Yang Li, Chunlin Zhang, Haitao Yu, Zhenwei Feng, Xin Gou and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wei ShiDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0009-0008-8078-3872
Xiang ZhouDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xinyuan LiDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xiang PengDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Guo ChenDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yang LiDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chunlin ZhangDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Haitao YuDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.ORCID 0000-0002-9745-8418
Zhenwei FengDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xin GouDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jing FanDepartment of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

Science and Technology Commission of Chongqing cstc2020jcyj-msxmX0285
6 · The paper itself

Abstract

Renal ischemia-reperfusion (I/R) injury is a leading cause of acute kidney injury (AKI), with high mortality. Recent studies have reported that human umbilical cord mesenchymal stem cells (HucMSCs) play an important role in repairing organ and tissue injuries because of their unique characteristics. However, the potential of HucMSC extracellular vesicles (HucMSC-EVs) to promote the repair of renal tubular cells remains to be explored. This study found that HucMSC-EVs derived from HucMSCs played a protective role and were associated with kidney I/R injury. We found that miR-148b-3p in HucMSC-EVs had a protective effect against kidney I/R injury. HK-2 cells overexpressing miR-148b-3p were protected against I/R injury by inhibiting apoptosis. Next, the target mRNA of miR-148b-3p was predicted online, and the target mRNA, pyruvate dehydrogenase kinase 4 (

Indexed as

Acute Kidney InjuryExtracellular VesiclesMesenchymal Stem CellsMicroRNAsReperfusion InjuryEndoplasmic Reticulum StressHumansKidneyProtein KinasesReperfusionUmbilical CordMicroRNAsProtein Kinasespyruvate dehydrogenase kinase 4apoptosisendoplasmic reticulum stressextracellular vesicleshuman umbilical cord mesenchymal stem cellsischemia/reperfusion injuryMicroRNA

Identifiers

PMID37240246
PMCPMC10219505
OpenAlexW4377140169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.