Evidence map›Paper›PMID 37240238›Full record

ReviewInternational journal of molecular sciences2023

Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis.

Vanessa G P Souza, Aisling Forder, Liam J Brockley, Michelle E Pewarchuk, Nikita Telkar, Rachel Paes de Araújo, Jessica Trejo, Katya Benard, Ana Laura Seneda, Iael W Minutentag and 7 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

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  16. Diagnosis and Management of Scalp Metastases: A Review.Diagnostics (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Vanessa G P SouzaBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-1561-1651
Aisling ForderBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Liam J BrockleyBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Michelle E PewarchukBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Nikita TelkarBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0002-3520-2353
Rachel Paes de AraújoMolecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil.ORCID 0000-0003-0712-8739
Jessica TrejoBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.ORCID 0000-0003-1308-4410
Katya BenardBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Ana Laura SenedaMolecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil.ORCID 0000-0002-5177-0887
Iael W MinutentagMolecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil.ORCID 0000-0002-2087-5686
Melis ErkanDepartment of Pathology and Laboratory Medicine, IWK Health Centre, Halifax, NS B3K 6R8, Canada.
Greg L StewartBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Erica N HasimotoDepartment of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil.
Cathie GarnisBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Wan L LamBritish Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
Victor D MartinezDepartment of Pathology and Laboratory Medicine, IWK Health Centre, Halifax, NS B3K 6R8, Canada.
Patricia P ReisMolecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu, SP 18618-687, Brazil.ORCID 0000-0003-3775-3797
Universidade Estadual Paulista (Unesp) · BRDalhousie University · CABC Children's Hospital · CAUniversity of British Columbia · CA

Funding

CIHR FRN-143345CIHR FRN-183775
6 · The paper itself

Abstract

Liquid biopsies have emerged as a promising tool for the detection of metastases as well as local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a patient's blood, urine, or other body fluids for the detection of biomarkers, including circulating tumor cells or tumor-derived DNA/RNA that have been shed into the bloodstream. Studies have shown that liquid biopsies can detect lung cancer metastases with high accuracy and sensitivity, even before they are visible on imaging scans. Such tests are valuable for early intervention and personalized treatment, aiming to improve patient outcomes. Liquid biopsies are also minimally invasive compared to traditional tissue biopsies, which require the removal of a sample of the tumor for further analysis. This makes liquid biopsies a more convenient and less risky option for patients, particularly those who are not good candidates for invasive procedures due to other medical conditions. While liquid biopsies for lung cancer metastases and relapse are still being developed and validated, they hold great promise for improving the detection and treatment of this deadly disease. Herein, we summarize available and novel approaches to liquid biopsy tests for lung cancer metastases and recurrence detection and describe their applications in clinical practice.

Indexed as

Lung NeoplasmsNeoplastic Cells, CirculatingBiomarkers, TumorBiopsyHumansLiquid BiopsyNeoplasm Recurrence, LocalBiomarkers, TumorCTCsctDNAliquid biopsylung cancermetastasisrecurrence

Identifiers

PMID37240238
PMCPMC10219023
OpenAlexW4377021542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.