Evidence map›Paper›PMID 37240221›Full record

ArticleInternational journal of molecular sciences2023

Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents.

Olga Michalak, Marcin Cybulski, Wojciech Szymanowski, Agnieszka Gornowicz, Marek Kubiszewski, Kinga Ostrowska, Piotr Krzeczyński, Krzysztof Bielawski, Bartosz Trzaskowski, Anna Bielawska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Olga MichalakChemistry Section, Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Marcin CybulskiChemistry Section, Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.ORCID 0000-0002-4560-9317
Wojciech SzymanowskiDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str., 15-089 Bialystok, Poland.
Agnieszka GornowiczDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str., 15-089 Bialystok, Poland.ORCID 0000-0002-0945-7870
Marek KubiszewskiAnalytical Research Section, Pharmaceutical Analysis Laboratory, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Kinga OstrowskaDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0002-5990-646X
Piotr KrzeczyńskiChemistry Section, Pharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.ORCID 0000-0002-4978-5887
Krzysztof BielawskiDepartment of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Bialystok, 1 Kilińskiego Str., 15-089 Bialystok, Poland.ORCID 0000-0003-3187-4205
Bartosz TrzaskowskiChemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, 2C Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0003-2385-1476
Anna BielawskaDepartment of Biotechnology, Medical University of Bialystok, 1 Kilińskiego Str., 15-089 Bialystok, Poland.

Funding

Polish Ministry of Education and Science 841333Polish Ministry of Education and Science B.SUB.23.420
6 · The paper itself

Abstract

A series of new ursolic acid (UA) derivatives substituted with various amino acids (AAs) or dipeptides (DP) at the C-3 position of the steroid skeleton was designed and synthesized. The compounds were obtained by the esterification of UA with the corresponding AAs. The cytotoxic activity of the synthesized conjugates was determined using the hormone-dependent breast cancer cell line MCF-7 and the triple-negative breast cancer cell line MDA. Three derivatives (

Indexed as

Antineoplastic AgentsCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipUrsolic AcidAntineoplastic AgentsUrsolic Acidamino acidantitumorcancerdockingursolic acid

Identifiers

PMID37240221
PMCPMC10219251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.