Evidence map›Paper›PMID 37240204›Full record

ArticleInternational journal of molecular sciences2023

Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma.

Maria Chiara Gelmi, Robert M Verdijk, Laurien E Houtzagers, Pieter A van der Velden, Wilma G M Kroes, Gregorius P M Luyten, T H Khanh Vu, Martine J Jager

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Maria Chiara GelmiDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0002-9099-009X
Robert M VerdijkDepartment of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.ORCID 0000-0003-1437-214X
Laurien E HoutzagersDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0003-1646-3723
Pieter A van der VeldenDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Wilma G M KroesDepartment of Clinical Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Gregorius P M LuytenDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
T H Khanh VuDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Martine J JagerDepartment of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0003-2261-3820
Leiden University Medical Center · NL

Funding

ASROO (Associazione Scientifica Retinoblastoma ed Oncologia Oculare) 2021-01Blinden-Penning foundation 2022-01Bontius Foundation 2022-01LUF W20408-2-98/01P.A. Jager - van Gelder Fund 2022-01Stichting Oogfonds Nederland 2022-01The Sam Fund 2022-01
6 · The paper itself

Abstract

Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to-mesenchymal transition (EMT)-related factors, and increased inflammation. We explored the role of MITF in Uveal Melanoma (UM) using a cohort of 64 patients enucleated at the Leiden University Medical Center. We analysed the relation between MITF expression and clinical, histopathological and genetic features of UM, as well as survival. We performed differential gene expression and gene set enrichment analysis using mRNA microarray data, comparing MITF-low with MITF-high UM. MITF expression was lower in heavily pigmented UM than in lightly pigmented UM (

Indexed as

MelanomaMicrophthalmosSkin NeoplasmsUveal NeoplasmsAntigens, DifferentiationCutaneous Malignant MelanomaHumansInflammationMicrophthalmia-Associated Transcription FactorUveal MelanomaAntigens, DifferentiationMicrophthalmia-Associated Transcription Factorchromosome statusMITF (Microphthalmia-associated transcription factor)pigmentationprognosisuveal melanoma

Identifiers

PMID37240204
PMCPMC10218684
OpenAlexW4377041288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.