Evidence map›Paper›PMID 37240193›Full record

ArticleInternational journal of molecular sciences2023

Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines.

Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Machi KannaDepartment of Medical Science, Graduate School of Medicine, Hiroshima University, Hiroshima 734-8551, Japan.
Yusuke NakatsuDepartment of Medical Science, Graduate School of Medicine, Hiroshima University, Hiroshima 734-8551, Japan.
Takeshi YamamotoyaDepartment of Medical Science, Graduate School of Medicine, Hiroshima University, Hiroshima 734-8551, Japan.
Akifumi KushiyamaDepartment of Pharmacotherapy, Meiji Pharmaceutical University, 2-522-1, Kiyose 204-8588, Japan.ORCID 0000-0003-1385-7487
Midori FujishiroDivision of Diabetes and Metabolic Diseases, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Hideyuki SakodaDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
Hiraku OnoDepartment of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Koji ArihiroDepartment of Anatomical Pathology, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
Tomoichiro AsanoDepartment of Medical Science, Graduate School of Medicine, Hiroshima University, Hiroshima 734-8551, Japan.
Hiroshima University · JPChiba University · JPHiroshima University Hospital · JPMeiji Pharmaceutical University · JPNihon University · JPUniversity of Miyazaki · JP

Funding

Grant-in-Aid for Scientific Research (B) 17H04200Grant-in-Aid for Scientific Research (B) 20H03732Grant-in-Aid for Scientific Research (C) 22K08077
6 · The paper itself

Abstract

Our previous studies using rodent models have suggested an essential role for Pin1 in the pathogenesis of non-alcoholic steatohepatitis (NASH). In addition, interestingly, serum Pin1 elevation has been reported in NASH patients. However, no studies have as yet examined the Pin1 expression level in human NASH livers. To clarify this issue, we investigated the expression level and subcellular distribution of Pin1 in liver specimens obtained using needle-biopsy samples from patients with NASH and healthy liver donors. Immunostaining using anti-Pin1 antibody revealed the Pin1 expression level to be significantly higher, particularly in nuclei, in the livers of NASH patients than those of healthy donors. In the samples from patients with NASH, the amount of nuclear Pin1 was revealed to be negatively related to serum alanine aminotransferase (ALT), while tendencies to be associated with other serum parameters such as aspartate aminotransferase (AST) and platelet number were noted but did not reach statistical significance. Such unclear results and the lack of a significant relationship might well be attributable to our small number of NASH liver samples (

Indexed as

Carcinoma, HepatocellularHypercholesterolemiaLiver NeoplasmsNon-alcoholic Fatty Liver DiseaseCell LineFatty Acids, NonesterifiedHumansNIMA-Interacting Peptidylprolyl IsomerasePeptidylprolyl IsomeraseFatty Acids, NonesterifiedNIMA-Interacting Peptidylprolyl IsomerasePeptidylprolyl Isomeraseliver biopsyNASHPin1

Identifiers

PMID37240193
PMCPMC10218692
OpenAlexW4376875369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.