Evidence map›Paper›PMID 37240086›Full record

ArticleInternational journal of molecular sciences2023

Preparation of Melatonin-Loaded Nanoparticles with Targeting and Sustained Release Function and Their Application in Osteoarthritis.

Haifeng Liang, Yiran Yan, Wei Sun, Xiaogang Ma, Zhiwen Su, Zhongxun Liu, Yan Chen, Bo Yu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haifeng LiangOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Yiran YanOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.ORCID 0000-0002-7123-7342
Wei SunOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Xiaogang MaOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhiwen SuOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhongxun LiuOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Yan ChenUltrasound Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Bo YuOrthopedic and Traumatology Department, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Zhujiang Hospital · CNSouthern Medical University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2019A1515011638Guangdong Basic and Applied Basic Research Foundation 2020A1515010055Guangdong Basic and Applied Basic Research Foundation 2022A1515011292Guangzhou Science and Technology Plan Project 202002030485National Natural Science Foundation of China 81871355National Natural Science Foundation of China 81974323Natural Science Foundation of Guangdong Province 2018A030313078
6 · The paper itself

Abstract

(1) The vicious cycle of innate immune response and reactive oxygen species (ROS) generation is an important pathological process of osteoarthritis (OA). Melatonin may be a new hope for the treatment of OA because of its antioxidant capacity. However, the mechanism of melatonin in the treatment of OA is still not completely clear, and the physiological characteristics of articular cartilage make melatonin unable to play a long-term role in OA. (2) The effects of melatonin on ROS and the innate immune response system in OA chondrocytes and the therapeutic effect in vivo were evaluated. Then, a melatonin-loaded nano-delivery system (MT@PLGA-COLBP) was prepared and characterized. Finally, the behavior of MT@PLGA-COLPB in cartilage and the therapeutic effect in OA mice were evaluated. (3) Melatonin can inhibit the activation of the innate immune system by inhibiting the TLR2/4-MyD88-NFκB signal pathway and scavenging ROS, thus improving cartilage matrix metabolism and delaying the progression of OA in vivo. MT@PLGA-COLBP can reach the interior of cartilage and complete the accumulation in OA knee joints. At the same time, it can reduce the number of intra-articular injections and improve the utilization rate of melatonin in vivo. (4) This work provides a new idea for the treatment of osteoarthritis, updates the mechanism of melatonin in the treatment of osteoarthritis, and highlights the application prospect of PLGA@MT-COLBP nanoparticles in preventing OA.

Indexed as

Cartilage, ArticularMelatoninNanoparticlesOsteoarthritisAnimalsChondrocytesDelayed-Action PreparationsMicePolylactic Acid-Polyglycolic Acid CopolymerReactive Oxygen SpeciesDelayed-Action PreparationsMelatoninPolylactic Acid-Polyglycolic Acid CopolymerReactive Oxygen SpeciesmelatoninnanoparticlesOAPLGAROSTLR

Identifiers

PMID37240086
PMCPMC10217911
OpenAlexW4378516817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.