Evidence map›Paper›PMID 37240083›Full record

ArticleInternational journal of molecular sciences2023

AEC and AFMSC Transplantation Preserves Fertility of Experimentally Induced Rat Varicocele by Expressing Differential Regenerative Mechanisms.

Alessia Peserico, Barbara Barboni, Valentina Russo, Delia Nardinocchi, Maura Turriani, Costanza Cimini, Nicola Bernabò, Ornella Parolini, Antonietta Rosa Silini, Ivana Antonucci and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Recent Trends in the Management of Varicocele.Journal of clinical medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Alessia PesericoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0003-2025-2419
Barbara BarboniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0003-0231-8066
Valentina RussoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0003-4368-2534
Delia NardinocchiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.
Maura TurrianiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.
Costanza CiminiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.
Nicola BernabòDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0001-5140-9656
Ornella ParoliniDepartment of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Largo Vito, 1, 00168 Rome, Italy.ORCID 0000-0002-5211-6430
Antonietta Rosa SiliniCentro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy.ORCID 0000-0001-6208-3583
Ivana AntonucciDepartment of Oral Sciences, Nano and Biotechnologies, "G. d'Annunzio" University, Via dei Vestini 31, 66013 Chieti, Italy.ORCID 0000-0002-6594-2272
Liborio StuppiaDepartment of Oral Sciences, Nano and Biotechnologies, "G. d'Annunzio" University, Via dei Vestini 31, 66013 Chieti, Italy.
Paolo BerardinelliDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.
Ilaria FalangaMedline Srl, Via Galileo Ferraris 1, 84018 Scafati, Italy.
Davide PerruzzaReproductive Medicine Unit, S.I.S.Me.R., Via Mazzini 12, 40138 Bologna, Italy.
Luca ValbonettiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0001-5914-615X
Annunziata MauroDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Via R. Balzarini 1, 64100 Teramo, Italy.ORCID 0000-0003-3907-0244
University of Teramo · ITUniversity of Chieti-Pescara · ITFondazione Poliambulanza Istituto Ospedaliero · ITUniversità Cattolica del Sacro Cuore · IT

Funding

European Union-Next Generation EU. Project Code: ECS00000041; Project CUP: C43C22000380007; Project Title: Innovation, digitalization, and sustainability for the diffused economy in Central Italy-VITALITY. ECS00000041
6 · The paper itself

Abstract

Amniotic membrane and amniotic fluid derived cells are regarded as a promising stem cell source for developing regenerative medicine techniques, although they have never been tested on male infertility diseases such as varicocele (VAR). The current study aimed to examine the effects of two distinct cell sources, human Amniotic Fluid Mesenchymal Stromal Cells (hAFMSCs) and amniotic epithelial cells (hAECs), on male fertility outcomes in a rat induced VAR model. To explain cell-dependent enhancement of reproductive outcomes in rats transplanted with hAECs and hAFMSCs, insights on testis morphology, endocannabinoid system (ECS) expression and inflammatory tissue response have been carried out alongside cell homing assessment. Both cell types survived 120 days post-transplantation by modulating the ECS main components, promoting proregenerative M2 macrophages (Mφ) recruitment and a favorable anti-inflammatory

Indexed as

Infertility, MaleVaricoceleAmnionAmniotic FluidAnimalsCell DifferentiationEpithelial CellsFertilityHumansMaleRatsamniotic epithelial cellsamniotic fluid derived cellsamniotic membrane derived cellsendocannabinoid systemhuman amniotic fluid mesenchymal stromal cellsimmunomodulationmale fertilitypreclinical in vivo studyrat modelregenerative medicinespermatogenesisvaricocele

Identifiers

PMID37240083
PMCPMC10218139
OpenAlexW4378516346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.