Evidence map›Paper›PMID 37239920›Full record

ArticleInternational journal of molecular sciences2023

Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network.

Sonia Vázquez-Morón, María Iglesias-Caballero, José Antonio Lepe, Federico Garcia, Santiago Melón, José M Marimon, Darío García de Viedma, Maria Dolores Folgueira, Juan Carlos Galán, Carla López-Causapé and 13 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sonia Vázquez-MorónRespiratory Viruses and Influenza Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0002-0977-741X
María Iglesias-CaballeroRespiratory Viruses and Influenza Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.
José Antonio LepeMicrobiology Service, Hospital Universitario Virgen del Rocio, 41013 Sevilla, Spain.
Federico GarciaMicrobiology Service, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria Ibs. Granada, 18016 Granada, Spain.ORCID 0000-0001-7611-781X
Santiago MelónMicrobiology Service, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.ORCID 0000-0001-5770-7902
José M MarimonMicrobiology Service, Instituto de Investigación Sanitaria Biodonostia, Hospital Universitario Donostia, 20014 Donostia-San Sebastian, Spain.ORCID 0000-0002-2787-7094
Darío García de ViedmaMicrobiology Service, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, 28007 Madrid, Spain.
Maria Dolores FolgueiraMicrobiology Department, Hospital Universitario 12 de Octubre, Biomedical Research Institute imas12, 28041 Madrid, Spain.ORCID 0000-0002-3730-015X
Juan Carlos GalánCIBER de Epidemiología y Salud Pública (CIBERESP), ISCIII, 28029 Madrid, Spain.ORCID 0000-0002-8447-0960
Carla López-CausapéMicrobiology Service, Hospital Universitario Son Espases, 07120 Palma de Mallorca, Spain.
Rafael Benito-RuescaMicrobiology Service, Hospital Clínico Universitario Lozano Blesa, Departamento de Microbiología, Facultad de Medicina, Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0001-5134-1006
Julia Alcoba-FlorezMicrobiology Service, Hospital Universitario Ntra. Sra de Candelaria, 38010 Santa Cruz de Tenerife, Spain.
Fernando Gonzalez CandelasCIBER de Epidemiología y Salud Pública (CIBERESP), ISCIII, 28029 Madrid, Spain.ORCID 0000-0002-0879-5798
María de ToroPlataforma de Genómica y Bioinformática, Centro de Investigación Biomédica de La Rioja (CIBIR), 26006 Logroño, Spain.ORCID 0000-0003-3329-0203
Miguel FajardoMicrobiology Service, Hospital Universitario de Badajoz, 06080 Badajoz, Spain.
Carmen EzpeletaComplejo Hospitalario de Navarra and Navarra De Servicios Y Tecnologías S A (NASERTIC), 31008 Pamplona, Spain.
Fernando LázaroMicrobiology Service, Hospital Universitario La Paz, 28046 Madrid, Spain.
Sonia Pérez CastroMicrobiology Service, Complexo Hospitalario Universitario de Vigo, 36204 Vigo, Spain.ORCID 0000-0003-1734-1904
Isabel CuestaBioinformatics Unit, Unidades Centrales Científico Técnicas, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.
Angel ZaballosGenomics Unit, Unidades Centrales Científico Técnicas, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0002-7555-5815
Francisco PozoRespiratory Viruses and Influenza Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0003-1828-733X
Inmaculada CasasRespiratory Viruses and Influenza Unit, National Centre for Microbiology, Instituto de Salud Carlos III, 28222 Majadahonda, Spain.ORCID 0000-0003-1840-1198
On Behalf Of Relecov Network Members

Funding

Cabildo Insular de Tenerife CGIEU0000219140European Centre for Disease Prevention and Control ECDC/HERA/2021/024 ECD.12241Fundación Canaria Instituto de Investigación Sanitaria de Canarias PIFIISC 21/37Instituto de Salud Carlos III COV20_00679_MPY 222/20UNESPA MPY 226/22
6 · The paper itself

Abstract

Millions of SARS-CoV-2 whole genome sequences have been generated to date. However, good quality data and adequate surveillance systems are required to contribute to meaningful surveillance in public health. In this context, the network of Spanish laboratories for coronavirus (RELECOV) was created with the main goal of promoting actions to speed up the detection, analyses, and evaluation of SARS-CoV-2 at a national level, partially structured and financed by an ECDC-HERA-Incubator action (ECDC/GRANT/2021/024). A SARS-CoV-2 sequencing quality control assessment (QCA) was developed to evaluate the network's technical capacity. QCA full panel results showed a lower hit rate for lineage assignment compared to that obtained for variants. Genomic data comprising 48,578 viral genomes were studied and evaluated to monitor SARS-CoV-2. The developed network actions showed a 36% increase in sharing viral sequences. In addition, analysis of lineage/sublineage-defining mutations to track the virus showed characteristic mutation profiles for the Delta and Omicron variants. Further, phylogenetic analyses strongly correlated with different variant clusters, obtaining a robust reference tree. The RELECOV network has made it possible to improve and enhance the genomic surveillance of SARS-CoV-2 in Spain. It has provided and evaluated genomic tools for viral genome monitoring and characterization that make it possible to increase knowledge efficiently and quickly, promoting the genomic surveillance of SARS-CoV-2 in Spain.

Indexed as

COVID-19SARS-CoV-2GenomicsHumansMutationPhylogenySpaingenomic surveillance Spainlaboratory network RELECOVlineagesmutationnational QCAphylogenySARS-CoV-2VOCs

Identifiers

PMID37239920
PMCPMC10218691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.