Evidence map›Paper›PMID 37239872›Full record

ArticleInternational journal of molecular sciences2023

Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose.

Serena Ruggieri, Alessandra Aiello, Carla Tortorella, Assunta Navarra, Valentina Vanini, Silvia Meschi, Daniele Lapa, Shalom Haggiag, Luca Prosperini, Gilda Cuzzi and 12 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
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  8. Review
  9. COVID-19 Pandemic: Therapeutic Strategies and Vaccines.International journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 1 country.

Serena RuggieriDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0001-5287-3290
Alessandra AielloTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.ORCID 0000-0003-2681-9383
Carla TortorellaDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Assunta NavarraClinical Epidemiology Unit, National Institute for Infectious Disease Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.ORCID 0000-0002-3662-4312
Valentina VaniniTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Silvia MeschiLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Daniele LapaLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Shalom HaggiagDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0002-5569-4121
Luca ProsperiniDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Gilda CuzziTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Andrea SalmiTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Maria Esmeralda QuartuccioDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Anna Maria Gerarda AlteraTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Anna Rosa GarbugliaLaboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Tommaso Ascoli BartoliClinical Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Simonetta GalganiDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Stefania NotariCellular Immunology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Chiara AgratiCellular Immunology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.
Vincenzo PuroUOC Emerging Infections and Centro di Riferimento AIDS (CRAIDS), National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.ORCID 0000-0003-0291-4490
Emanuele NicastriClinical Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.ORCID 0000-0002-5606-8712
Claudio GasperiniDepartment of Neurosciences, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, 00149 Rome, Italy.ORCID 0000-0001-8360-4376
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITCarlo Forlanini Hospital · IT

Funding

Camera di Commercio, Industria e Artigianato di Roma resolution number 395 on 25 May 2021European Project SHARP 848096Ministero della Salute Ricerca Corrente on emerging infections
6 · The paper itself

Abstract

This study characterizes antibody and T-cell immune responses over time until the booster dose of COronaVIrus Disease 2019 (COVID-19) vaccines in patients with multiple sclerosis (PwMS) undergoing different disease-modifying treatments (DMTs). We prospectively enrolled 134 PwMS and 99 health care workers (HCWs) having completed the two-dose schedule of a COVID-19 mRNA vaccine within the last 2-4 weeks (T0) and followed them 24 weeks after the first dose (T1) and 4-6 weeks after the booster (T2). PwMS presented a significant reduction in the seroconversion rate and anti-receptor-binding domain (RBD)-Immunoglobulin (IgG) titers from T0 to T1 (

Indexed as

COVID-19Multiple SclerosisAntibodies, ViralCOVID-19 VaccinesHumansImmunityImmunoglobulin GmRNA VaccinesRNA, MessengerSARS-CoV-2T-LymphocytesVaccinationAntibodies, ViralCOVID-19 VaccinesImmunoglobulin GmRNA VaccinesRNA, Messengerantibody responseCOVID-19mRNA vaccinesmultiple sclerosisSARS-CoV-2T-cell response

Identifiers

PMID37239872
PMCPMC10218688
OpenAlexW4376115473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.