Evidence map›Paper›PMID 37239853›Full record

ArticleInternational journal of molecular sciences2023

Inflammasome Activity in the Skeletal Muscle and Heart of Rodent Models for Duchenne Muscular Dystrophy.

Zsófia Onódi, Petra Lujza Szabó, Dániel Kucsera, Péter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y Oudit, Bruno K Podesser, Péter Ferdinandy, Zoltán V Varga and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Does Vitamin B6 Act as an Exercise Mimetic in Skeletal Muscle?International journal of molecular sciences · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Zsófia OnódiDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary.
Petra Lujza SzabóLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5465-8391
Dániel KucseraDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0001-9446-847X
Péter PokreiszLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-2810-9000
Christopher DostalLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Karlheinz HilberDepartment of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Gavin Y OuditDivision of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-9154-9028
Bruno K PodesserLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-4641-7202
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary.
Zoltán V VargaDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-2758-0784
Attila KissLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4652-1998
Medical University of Vienna · ATSemmelweis University · HUUniversity of Alberta · CA

Funding

Austrian Science Fund FWF P 35542
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is characterized by wasting of muscles that leads to difficulty moving and premature death, mainly from heart failure. Glucocorticoids are applied in the management of the disease, supporting the hypothesis that inflammation may be driver as well as target. However, the inflammatory mechanisms during progression of cardiac and skeletal muscle dysfunction are still not well characterized. Our objective was to characterize the inflammasomes in myocardial and skeletal muscle in rodent models of DMD. Gastrocnemius and heart samples were collected from

Indexed as

Muscular Dystrophy, DuchenneAnimalsCytokinesDisease Models, AnimalInflammasomesInflammationMiceMice, Inbred mdxMuscle, SkeletalRatsRodentiaCytokinesInflammasomescardiomyopathyheart failureinflammationmuscular dystrophyskeletal muscle

Identifiers

PMID37239853
PMCPMC10218525
OpenAlexW4376115746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.