Evidence map›Paper›PMID 37239846›Full record

SynthesisInternational journal of molecular sciences2023

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization.

Esther Clavero, José Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belém Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A T Hildebrandt, Niels Weinhold and 62 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Multiple myeloma.Nature reviews. Disease primers · 2024
    Review
  10. Article
  11. Review
  12. Autophagy-related mechanisms for treatment of multiple myeloma.Cancer drug resistance (Alhambra, Calif.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

72 authors at 20 institutions in 18 countries.

Esther ClaveroHematology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain.
José Manuel Sanchez-MaldonadoGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.ORCID 0000-0002-4651-3675
Angelica MacaudaGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Rob Ter HorstDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Belém Sampaio-MarquesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0001-6580-0971
Artur JurczyszynPlasma Cell Dyscrasias Center, Department of Hematology, Jagiellonian University Medical College, 31-066 Kraków, Poland.ORCID 0000-0001-9796-8365
Alyssa Clay-GilmourDepartment of Biostatistics and Epidemiology, Arnold School of Public Health, University of South Carolina, Greenville, SC 29208, USA.
Angelika SteinGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Michelle A T HildebrandtDepartment of Lymphoma-Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Niels WeinholdMyeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Gabriele BudaHaematology Unit, Department of Clinical and Experimental Medicine, University of Pisa/AOUP, 56126 Pisa, Italy.
Ramón García-SanzDiagnostic Laboratory Unit in Hematology, University Hospital of Salamanca, IBSAL, CIBERONC, Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), 37007 Salamanca, Spain.
Waldemar TomczakDepartment of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-3205-5781
Ulla VogelNational Research Centre for the Working Environment, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-6807-1524
Andrés JerezDepartment of Hematology, Experimental Hematology Unit, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0002-2079-6638
Daria ZawirskaDepartment of Hematology, University Hospital, 30-688 Kraków, Poland.
Marzena WątekHolycross Medical Oncology Center, 25-735 Kielce, Poland.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Stefano LandiDepartment of Biology, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-8364-6357
John J SpinelliDivision of Population Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada.
Aleksandra ButrymDepartment of Cancer Prevention and Therapy, Wroclaw Medical University, 50-367 Wroclaw, Poland.ORCID 0000-0002-8199-2018
Abhishek KumarInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India.
Joaquín Martínez-LópezHospital 12 de Octubre, Complutense University, CNIO, CIBERONC, 28041 Madrid, Spain.
Sara GalimbertiHaematology Unit, Department of Clinical and Experimental Medicine, University of Pisa/AOUP, 56126 Pisa, Italy.ORCID 0000-0001-7899-5966
María Eugenia SarasqueteDiagnostic Laboratory Unit in Hematology, University Hospital of Salamanca, IBSAL, CIBERONC, Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), 37007 Salamanca, Spain.
Edyta SuboczDepartment of Hematology, Military Institute of Medicine, 04-141 Warsaw, Poland.ORCID 0000-0001-5225-3921
Elzbieta Iskierka-JażdżewskaDepartment of Hematology, Medical University of Lodz, 90-419 Lodz, Poland.ORCID 0000-0003-2772-8870
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC 3004, Australia.ORCID 0000-0003-4946-9099
Malwina Rybicka-RamosDepartment of Hematology, Specialist Hospital No. 1 in Bytom, Academy of Silesia, Faculty of Medicine, 40-055 Katowice, Poland.
Marcin KruszewskiDepartment of Hematology, University Hospital No. 2, 85-168 Bydgoszcz, Poland.
Niels AbildgaardDepartment of Hematology, Odense University Hospital, DK-5000 Odense, Denmark.
Francisco García VerdejoDepartment of Medical Oncology, Complejo Hospitalario de Jaén, 23007 Jaén, Spain.
Pedro Sánchez RoviraDepartment of Medical Oncology, Complejo Hospitalario de Jaén, 23007 Jaén, Spain.
Miguel Inacio da Silva FilhoDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany.
Katalin KadarSt Johns Hospital, 62769 Budapest, Hungary.ORCID 0009-0008-3445-1981
Małgorzata RaznyDepartment of Hematology, Rydygier Hospital, 31-826 Cracow, Poland.
Wendy CozenDivision of Hematology/Oncology, Department of Medicine, School of Medicine, Department of Pathology, School of Medicine, Susan and Henry Samueli College of Health Sciences, Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, CA 92697, USA.
Matteo PelosiniU.O. Dipartimento di Ematologia, Azienda USL Toscana Nord Ovest, 57124 Livorno, Italy.
Manuel JuradoHematology Department, Virgen de las Nieves University Hospital, 18012 Granada, Spain.
Parveen BhattiCancer Control Research, BC Cancer, Vancouver, BC V5Z 4E6, Canada.
Marek DudzinskiDepartment of Hematology, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.
Agnieszka Druzd-SitekDepartment of Lymphoproliferative Diseases, Maria Skłodowska Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Enrico OrciuoloHaematology Unit, Department of Clinical and Experimental Medicine, University of Pisa/AOUP, 56126 Pisa, Italy.
Yang LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-4022-7341
Aaron D NormanDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55902, USA.
Jan Maciej ZauchaDepartment of Hematology and Transplantology, Medical University of Gdansk, 80-210 Gdansk, Poland.ORCID 0000-0002-0986-8936
Rui Manuel ReisLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal and ICVS/3B's-PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal.ORCID 0000-0002-9639-7940
Miroslaw MarkiewiczDepartment of Hematology, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszow, 35-310 Rzeszow, Poland.ORCID 0000-0002-8550-8908
Juan José Rodríguez SevillaDepartment of Hematology, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-4741-7925
Vibeke AndersenMolecular Diagnostics and Clinical Research Unit, Institute of Regional Health Research, University Hospital of Southern Denmark, DK-6200 Aabenraa, Denmark.ORCID 0000-0002-0127-2863
Krzysztof JamroziakDepartment of Hematology, Transplantology and Internal Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland.
Kari HemminkiDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.ORCID 0000-0002-2769-3316
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vicent RajkumarDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA.
Grzegorz MazurDepartment of Internal Diseases, Occupational Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, 50-368 Wroclaw, Poland.ORCID 0000-0001-6610-2008
Shaji K KumarDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA.
Paula LudovicoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0003-4130-7167
Arnon NaglerHematology Division, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Charles DumontetUMR INSERM 1052/CNRS 5286, University of Lyon, Hospices Civils de Lyon, 69008 Lyon, France.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Judit VarkonyiSemmelweis University, 1083 Budapest, Hungary.
Nicola J CampDivision of Hematology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Elad ZivDepartment of Medicine, University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA.
Annette Juul VangstedDepartment of Hematology, Rigshospitalet, Copenhagen University, DK-2100 Copenhagen, Denmark.
Elizabeth E BrownDepartment of Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Daniele CampaDepartment of Biology, University of Pisa, 56126 Pisa, Italy.
Celine M VachonDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55902, USA.
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-4261-4583
Asta FörstiDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.ORCID 0000-0002-9857-4728
Juan SainzGenomic Oncology Area, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.ORCID 0000-0002-9355-2423
German Cancer Research Center · DEUniversity of Pisa · ITNational Institutes of Health · USComplejo Hospitalario de Jaén · ESInstituto de Investigación Biomédica de Salamanca · ESMayo Clinic in Arizona · USMayo Clinic in Florida · USUniversidad de Granada · ESUniversity of Minho · PTUniversity of Rzeszów · PLWroclaw Medical University · PLAustrian Academy of Sciences · ATAzienda Usl Toscana Centro · ITCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAGdańsk Medical University · PLHeidelberg University · DEHospital de Câncer de Barretos · BRHospital Del Mar · ESHospital Universitario 12 De Octubre · ESHospital Universitario Virgen de las Nieves · ES

Funding

Epigenetic contribution to the excess risk of MGUS in African AmericansU01CA249955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROWN, ELIZABETH E · 2021 to 2025
$3.0M
Molecular characterization of myeloma and related asymptomatic precursor statesR01CA186646 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BROWN, ELIZABETH E, VACHON, CELINE M · 2014 to 2018
$3.0M
Instituto de Salud Carlos III PI17/02256Instituto de Salud Carlos III PI20/01845National Cancer Institute of the National Institutes of Health R01CA186646National Cancer Institute of the National Institutes of Health U01CA249955 (EEB)NCI NIH HHS R01 CA186646NCI NIH HHS U01 CA249955the CRIS foundation against cancer, from the Cancer Network of Excellence RD12/10 Red de Cáncerthe Dietmar Hopp Foundation and the German Ministry of Education and Science BMBF: CLIOMMICS [01ZX1309]
6 · The paper itself

Abstract

Multiple myeloma (MM) arises following malignant proliferation of plasma cells in the bone marrow, that secrete high amounts of specific monoclonal immunoglobulins or light chains, resulting in the massive production of unfolded or misfolded proteins. Autophagy can have a dual role in tumorigenesis, by eliminating these abnormal proteins to avoid cancer development, but also ensuring MM cell survival and promoting resistance to treatments. To date no studies have determined the impact of genetic variation in autophagy-related genes on MM risk. We performed meta-analysis of germline genetic data on 234 autophagy-related genes from three independent study populations including 13,387 subjects of European ancestry (6863 MM patients and 6524 controls) and examined correlations of statistically significant single nucleotide polymorphisms (SNPs;

Indexed as

Multiple MyelomaAutophagyBiomarkersHumansImmunoglobulin MLeukocytes, MononuclearBiomarkersImmunoglobulin Mautophagygenetic susceptibilitygenetic variantsmultiple myeloma

Identifiers

PMID37239846
PMCPMC10218542
OpenAlexW4378516543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.