Evidence map›Paper›PMID 37239471›Full record

ArticleGenes2023

Differential Regulation of POC5 by ERα in Human Normal and Scoliotic Cells.

Amani Hassan, Edward T Bagu, Shunmoogum A Patten, Sirinart Molidperee, Stefan Parent, Soraya Barchi, Isabelle Villemure, André Tremblay, Florina Moldovan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Amani HassanResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.ORCID 0000-0002-7542-6976
Edward T BaguDepartment of Basic Biomedical Sciences, Sanford Medical School, University of South Dakota, Vermillion, SD 57069, USA.
Shunmoogum A PattenINRS Center Armand-Frappier Santé Biotechnologie, 531 Boul des Prairies, Laval, QC H7V 1B7, Canada.
Sirinart MolidpereeResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.
Stefan ParentResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.
Soraya BarchiResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.
Isabelle VillemureDepartment of Mechanical Engineering, Polytechnique Montréal, 2500 Chemin de Polytechnique, Montréal, QC H3T 1J4, Canada.
André TremblayResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.ORCID 0000-0003-1547-9846
Florina MoldovanResearch Center CHU Sainte-Justine, 3175 Chemin de la Cote-Sainte-Catherine, Montréal, QC H3T 1C5, Canada.ORCID 0000-0002-3028-672X
Centre Hospitalier Universitaire Sainte-Justine · CAInstitut National de la Recherche Scientifique · CAPolytechnique Montréal · CAUniversity of South Dakota · US

Funding

CIHR
6 · The paper itself

Abstract

Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity. The incidence of AIS in females is 8.4 times higher than in males. Several hypotheses on the role of estrogen have been postulated for the progression of AIS. Recently, Centriolar protein gene POC5 (

Indexed as

Carrier ProteinsEstrogen Receptor alphaScoliosisEstradiolEstrogensHumansCarrier ProteinsEstradiolEstrogen Receptor alphaEstrogensPOC5 protein, human17β-estradiolcontrol NOBsE2estrogenestrogen receptorestrogen resistancemutant POC5A429V AIS osteoblastsosteoblastsPOC5puberty

Identifiers

PMID37239471
PMCPMC10218682
OpenAlexW4377138706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.