ReviewBrain sciences2023
Pineal Abnormalities in Psychosis and Mood Disorders: A Systematic Review.
Review in Brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Psychotic major depressive disorder and rapid eye movement sleep behavior disorder cooccurring with a pineal cyst: a case report with neuroimaging insights in a 15-year-old female.BMC psychiatry · 2025Article
- Reduced Pineal Gland Volume in Oncology Patients: Association with Chemotherapy Duration.Medicina (Kaunas, Lithuania) · 2025Article
- Pineal cyst in bipolar patient with normolithiaemia and positive fibromyalgic tender points.Radiology case reports · 2025Article
- Sleep Matters in Chronotype and Mental Health Association: Evidence from the UK and Germany.Brain sciences · 2024Article
- Sleep quality mediates the association between chronotype and mental health in young Indian adults.Npj mental health research · 2024Article
- The Association of Redox Regulatory Drug Target Genes with Psychiatric Disorders: A Mendelian Randomization Study.Antioxidants (Basel, Switzerland) · 2024Article
- LncRNA-mir3471-limd1 regulatory network plays critical roles in HIBD.Experimental brain research · 2024Article
- Turn off that night light! Light-at-night as a stressor for adolescents.Frontiers in neuroscience · 2024Review
- The brain in chronic insomnia and anxiety disorder: a combined structural and functional fMRI study.Frontiers in psychiatry · 2024Article
- Case report: A case of anti-recoverin antibody-positive encephalitis exhibiting Cotard and Capgras delusions that was successfully treated with electroconvulsive therapy.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pineal gland (PG) is a small interhemispheric brain structure that influences human physiology in many ways, most importantly via secretion of the hormone melatonin which is known to regulate sleep and wakefulness. Here, we systematically reviewed existing neuroimaging studies of PG structure, and/or melatonin release (MLT) in psychosis and mood disorders. Medline, PubMed, and Web of Science databases were searched (on 3 February 2023), yielding 36 studies (8 PG volume, 24 MLT). The findings showed smaller-than-normal PG volume in people with schizophrenia, regardless of symptom severity and illness stage; and smaller-than-normal PG volume in major depression, with some indication of this being present only in certain subgroups, or in those with high scores on the 'loss of interest' symptom. There was considerable evidence of lower-than-normal MLT as well as aberrant MLT secretion pattern in schizophrenia. A similar picture, though less consistent than that seen in schizophrenia, emerged in major depression and bipolar disorder, with some evidence of a transient lowering of MLT following the initiation of certain antidepressants in drug-withdrawn patients. Overall, PG and MLT aberrations appear to represent transdiagnostic biomarkers for psychosis and mood disorders, but further work is needed to establish their clinical correlates and treatment implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.