Evidence map›Paper›PMID 37239115›Full record

ReviewBiomedicines2023

Molecular Pathogenesis of Human Immunodeficiency Virus-Associated Disease of Oropharyngeal Mucosal Epithelium.

Sharof M Tugizov

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Sharof M TugizovDepartment of Medicine, School of Medicine, University of California, San Francisco, CA 94143, USA.ORCID 0000-0002-3743-4334
University of California, San Francisco · US

Funding

Role of oral herpesvirus microbiota in pathogenesis of HIV mother to child transmissionR01DE028129 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TUGIZOV, SHAROF M · 2018 to 2022
$2.6M
Role of HIV in acceleration of HPV malignancyR01CA232887 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TUGIZOV, SHAROF M · 2019 to 2023
$1.8M
NCI NIH HHS R01 CA232887NCI NIH HHS R01CA232887NIDCR NIH HHS R01 DE028129
6 · The paper itself

Abstract

The oropharyngeal mucosal epithelia have a polarized organization, which is critical for maintaining a highly efficient barrier as well as innate immune functions. In human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) disease, the barrier and innate immune functions of the oral mucosa are impaired via a number of mechanisms. The goal of this review was to discuss the molecular mechanisms of HIV/AIDS-associated changes in the oropharyngeal mucosa and their role in promoting HIV transmission and disease pathogenesis, notably the development of opportunistic infections, including human cytomegalovirus, herpes simplex virus, and Epstein-Barr virus. In addition, the significance of adult and newborn/infant oral mucosa in HIV resistance and transmission was analyzed. HIV/AIDS-associated changes in the oropharyngeal mucosal epithelium and their role in promoting human papillomavirus-positive and negative neoplastic malignancy are also discussed.

Indexed as

disruption of epithelial junctionshuman immunodeficiency virusoropharyngeal mucosal epitheliumreactivation of opportunistic infections

Identifiers

PMID37239115
PMCPMC10216750
OpenAlexW4376610746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.