Evidence map›Paper›PMID 37239022›Full record

ArticleBiomedicines2023

Characterization of Stimulatory Action on Voltage-Gated Na

Chih-Yu Ting, Chia-Lung Shih, Meng-Cheng Yu, Chao-Liang Wu, Sheng-Nan Wu

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chih-Yu TingDepartment of Emergency Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.
Chia-Lung ShihClinical Research Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.ORCID 0000-0002-5295-6667
Meng-Cheng YuDepartment of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.
Chao-Liang WuClinical Research Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City 60002, Taiwan.ORCID 0000-0001-7821-9406
Sheng-Nan WuDepartment of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan.ORCID 0000-0002-5208-3253
Chia-Yi Christian Hospital · TWNational Cheng Kung University · TWNational Sun Yat-sen University · TW

Funding

Ministry of Science and Technology -110-2320-B-006-028Ministry of Science and Technology -111-2314-B-006-028Ministry of Science and Technology -112-2923-B-006-001Taiwan and Ditmanson Medical Foundation Chia-Yi Christian Hospital Research Program
6 · The paper itself

Abstract

Omecamtiv mecarbil (OM, CK-1827452) is recognized as an activator of myosin and has been demonstrated to be beneficial for the treatment of systolic heart failure. However, the mechanisms by which this compound interacts with ionic currents in electrically excitable cells remain largely unknown. The objective of this study was to investigate the effects of OM on ionic currents in GH3 pituitary cells and Neuro-2a neuroblastoma cells. In GH

Indexed as

cumulative inactivationlate Na+ currentmyosin activatoromecamtiv mecarbilslow inactivationtransient Na+ currentvoltage-gated Na+ currentwindow Na+ current

Identifiers

PMID37239022
PMCPMC10216194
OpenAlexW4378515712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.