Evidence map›Paper›PMID 37238940›Full record

ArticleBiomedicines2023

Atenolol Ameliorates Skeletal Muscle Atrophy and Oxidative Stress Induced by Cast Immobilization in Rats.

Anand Kumar, Chaitany Jayprakash Raorane, Deepak Rawat, Priyanka Prajapati, Ritu Raj, Dinesh Kumar, Seong-Cheol Kim, Vinit Raj, Sapana Kushwaha

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anand KumarDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India.ORCID 0000-0002-0001-6710
Chaitany Jayprakash RaoraneSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Deepak RawatDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India.
Priyanka PrajapatiDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India.
Ritu RajCentre of Biomedical Research, SGPGIMS Campus, Lucknow 226014, India.
Dinesh KumarCentre of Biomedical Research, SGPGIMS Campus, Lucknow 226014, India.ORCID 0000-0001-8079-6739
Seong-Cheol KimSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Vinit RajSchool of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Sapana KushwahaNational Institutes of Pharmaceutical Education and Research, Raebareli (NIPER-R), New Transit Campus, Bijnor-Sisendi Road, Lucknow 226002, India.ORCID 0000-0001-8825-3034
Babasaheb Bhimrao Ambedkar University · INYeungnam University · KRSanjay Gandhi Post Graduate Institute of Medical Sciences · INNational Institute of Pharmaceutical Education and Research · IN

Funding

Basic Science Research Program through the National Research Foundation of Korea (NRF) 2020R1I1A3052258University Grants Commission (UGC) startup grant F. 30-460/2019 (BSR
6 · The paper itself

Abstract

(1) Background: Skeletal muscle atrophy is a common and debilitating condition associated with disease, bed rest, and inactivity. We aimed to investigate the effect of atenolol (ATN) on cast immobilization (IM)-induced skeletal muscle loss. (2) Methods: Eighteen male albino Wistar rats were divided into three groups: a control group, an IM group (14 days), and an IM+ATN group (10 mg/kg, orally for 14 days). After the last dose of atenolol, forced swimming test, rotarod test, and footprint analysis were performed, and skeletal muscle loss was determined. Animals were then sacrificed. Serum and gastrocnemius (GN) muscles were then collected, serum creatinine, GN muscle antioxidant, and oxidative stress levels were determined, and histopathology and

Indexed as

atenololcast immobilizationmetabolomicsoxidative stressskeletal muscle atrophy

Identifiers

PMID37238940
PMCPMC10215752
OpenAlexW4366986626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.