Evidence map›Paper›PMID 37238699›Full record

Trial reportBiomolecules2023

Dopamine D

Mechelle M Lewis, Lauren J Van Scoy, Sol De Jesus, Jonathan G Hakun, Paul J Eslinger, Julio Fernandez-Mendoza, Lan Kong, Yang Yang, Bethany L Snyder, Natalia Loktionova and 4 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Impulse control disorders in Parkinson's disease patients treated with pramipexole and ropinirole: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Dopamine DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
  5. Concomitant activation of DResearch square · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Mechelle M LewisDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-1375-689X
Lauren J Van ScoyTranslational Brain Research Center, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-0984-1474
Sol De JesusDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Jonathan G HakunDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Paul J EslingerDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0002-6032-7801
Julio Fernandez-MendozaDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-9584-6161
Lan KongTranslational Brain Research Center, Penn State Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA 17033, USA.
Yang YangDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0001-6612-8865
Bethany L SnyderDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Natalia LoktionovaDepartment of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Sridhar DuvvuriCerevel Neurosciences LLC, Cambridge, MA 02141, USA.
David L GrayCerevel Neurosciences LLC, Cambridge, MA 02141, USA.
Xuemei HuangDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Richard B MailmanDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.ORCID 0000-0003-1353-2738
Pennsylvania State University · USCerevel Therapeutics (United States) · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological RelevanceU01NS112008 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI, KANTHASAMY, ANUMANTHA GOUNDER · 2019 to 2023
$5.5M
Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's DiseaseU01NS082151 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2012 to 2016
$4.2M
Structural MRI marker(s) of Parkinson's Disease's ProgressionR01NS060722 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HUANG, XUEMEI · 2009 to 2013
$2.9M
Discovery of functionally selective dopamine ligands for age-related cognitive declineRF1AG071675 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI DOKHOLYAN, NIKOLAY, MAILMAN, RICHARD B · 2021 to 2021
$1.5M
In vivo agonist molecular probes for the dopamine D1 receptorR01NS105471 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MAILMAN, RICHARD B, SHARMA, ARUN K · 2018 to 2020
$1.0M
Self-regulation of Health Promotion: the Roles of Momentary Variability in Working Memory Capacity and Neurocognitive AgingR00AG056670 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HAKUN, JONATHAN G. · 2019 to 2021
$721k
NOVEL MOLECULAR SITE FOR ANTIDOPAMINERGIC EFFECTSR01MH040537 · NIMH · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI MAILMAN, RICHARD B · 1985 to 2001
$506k
Communication quality analysis of end-of-life discussions by cliniciansR21NR017259 · NINR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI VAN SCOY, LAUREN JODI · 2018 to 2019
$442k
Self-regulation of Health Promotion: the Roles of Momentary Variability in Working Memory Capacity and Neurocognitive AgingK99AG056670 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI HAKUN, JONATHAN G. · 2017 to 2018
$201k
NIA NIH HHS R00 AG056670NIA NIH HHS RF1 AG071675NIH HHS AG056670NIH HHS MH040537NIH HHS NR017259NIH HHS NS060722NIH HHS NS082151NIH HHS NS112008NIH HHS TR002014NINDS NIH HHS R01 NS105471
6 · The paper itself

Abstract

Current pharmacotherapy has limited efficacy and/or intolerable side effects in late-stage Parkinson's disease (LsPD) patients whose daily life depends primarily on caregivers and palliative care. Clinical metrics inadequately gauge efficacy in LsPD patients. We explored if a D

Indexed as

Parkinson DiseaseAntiparkinson AgentsDopamineDopamine AgonistsHumansLevodopaAntiparkinson AgentsDopamineDopamine AgonistsLevodopaclinical trialdopamine D1 agonistsdopamine D1 receptorslate-stage Parkinson’s disease

Identifiers

PMID37238699
PMCPMC10216182
OpenAlexW4376614356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.