ArticleChildren (Basel, Switzerland)2023
Trends and Predictors of Pediatric Negative Appendectomy Rates: A Single-Centre Retrospective Study.
Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06462846 (Evaluation of Demographic and Clinical Characteristics and Intraoperative and Pathological Findings in Patients With Suspected Appendicitis Who Underwent Appendectomy in 5 Azar Hospital in 2022), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Demographic and Clinical Characteristics and Intraoperative and Pathological Findings in Patients With Suspected Appendicitis Who Underwent Appendectomy in 5 Azar Hospital in 2022
Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Contemporary National Inpatient Trends in appendectomy utilization and operative approach in the United States, 2016-2022.Surgery open science · 2026Article
- Agreement Between Intraoperative Findings and Histopathological Diagnosis and Their Association with Postoperative Outcomes in Acute Appendicitis.Diagnostics (Basel, Switzerland) · 2026Article
- Reactive lymphoid hyperplasia of the appendix in children: a descriptive analysis of accompanying neural and stromal features.Frontiers in pediatrics · 2026Article
- Dharma: A novel, clinically grounded machine learning framework for pediatric appendicitis-Diagnosis, severity assessment and evidence-based clinical decision support.PLOS digital health · 2026Article
- Article
- Salivary C-Reactive Protein: A Non-Invasive Alternative to Serum CRP in Pediatric Acute Appendicitis.Molecules (Basel, Switzerland) · 2025Article
- Acute Appendicitis or Appendiceal Diverticulitis? A Case Report and Systematic Literature Review.Clinics and practice · 2025Review
- Article
- Applying an explainable machine learning model might reduce the number of negative appendectomies in pediatric patients with a high probability of acute appendicitis.Scientific reports · 2024Article
- Management and Incidence ofJournal of clinical medicine · 2024Article
- Comparison of Clinical, Pathological, and Procedural Characteristics of Adult and Pediatric Acute Appendicitis before and during the COVID-19 Pandemic.Children (Basel, Switzerland) · 2024Article
- Suspected Simple Appendicitis in Children: Should We Use a Nonoperative, Antibiotic-Free Approach? An Observational Study.Children (Basel, Switzerland) · 2024Article
- Incidence and Management of Appendiceal Neuroendocrine Tumors in Pediatric Population: A Bicentric Experience with 6285 Appendectomies.Children (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppendectomy is still the standard treatment for acute appendicitis in the majority of centers. Despite all available diagnostic tools, the rates of negative appendectomies are still relatively high. This study aimed to determine negative appendectomy rates and to analyze the demographic and clinical data of the patients whose histopathology report was negative.
methodsAll patients younger than 18 years who underwent appendectomy for suspected acute appendicitis in the period from 1 January 2012 to 31 December 2021 were included in the single-center retrospective study. Electronic records and archives of histopathology reports were reviewed for patients with negative appendectomy. The primary outcome of this study was a negative appendectomy rate. Secondary outcomes comprehended the rate of appendectomies and the association of age, sex, body mass index (BMI), values of laboratory markers, scoring systems, and ultrasound reports with negative histopathology reports.
resultsDuring the study period, a total of 1646 appendectomies for suspected acute appendicitis were performed. In 244 patients, negative appendectomy was reported regarding the patients' pathohistology. In 39 of 244 patients, other pathologies were found, of which ovarian pathology (torsion and cysts) torsion of greater omentum and Meckel's diverticulitis were the most frequent. Finally, the ten-year negative appendectomy rate was 12.4% (205/1646). The median age was 12 years (interquartile range, IQR 9, 15). A slight female predominance was noted (52.5%). A significantly higher incidence of negative appendectomies was noted in girls, with a peak incidence between the ages of 10 and 15 years (
conclusionsThe majority of negative appendectomies were performed in children older than 9 years and most frequently in female children aged 10 to 15 years. In addition, female children have significantly lower BMI values compared to male children with negative appendectomy. An increase in the utilization of auxiliary diagnostic methods such as computed tomography could affect the reduction in the pediatric negative appendectomy rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.