Evidence map›Paper›PMID 37238119›Full record

ArticleAnimals : an open access journal from MDPI2023

Evaluation of Immune Nanoparticles for Rapid and Non-Specific Activation of Antiviral and Antibacterial Immune Responses in Cattle, Swine, and Poultry.

William H Wheat, Lyndah Chow, Alyssa M Betlach, Maria Pieters, Jade Kurihara, Cooper Dow, Valerie Johnson, Franklyn B Garry, Steven Dow

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

William H WheatDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-4229-3617
Lyndah ChowDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-6413-9517
Alyssa M BetlachSwine Veterinary Center, St. Peter, MN 56082, USA.
Maria PietersDepartment of Veterinary Population Medicine, Veterinary Diagnostic Laboratory and Swine Disease Eradication Center, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55455, USA.ORCID 0000-0001-9685-2037
Jade KuriharaDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Cooper DowIdaho State University, Pocatello, ID 83209, USA.
Valerie JohnsonCollege of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
Franklyn B GarryDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Steven DowDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Colorado State University · USIdaho State University · USMichigan State University · USUniversity of Minnesota · US

Funding

CTSA K12 Program at the University of MichiganK12TR004374 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, Leah Elizabeth Robinson · 2023 to 2026
$6.5M
NCATS NIH HHS K12 TR004374
6 · The paper itself

Abstract

Given the rapid potential spread of agricultural pathogens, and the lack of vaccines for many, there is an important unmet need for strategies to induce rapid and non-specific immunity against these viral and bacterial threats. One approach to the problem is to generate non-specific immune responses at mucosal surfaces to rapidly protect from entry and replication of both viral and bacterial pathogens. Using complexes of charged nanoparticle liposomes with both antiviral and antibacterial toll-like receptor (TLR) nucleic acid ligands (termed liposome-TLR complexes or

Indexed as

agriculturecountermeasurescytokinesimmunotherapyinnate immunitypandemic

Identifiers

PMID37238119
PMCPMC10215472
OpenAlexW4377137274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.