Evidence map›Paper›PMID 37238045›Full record

ReviewAnimals : an open access journal from MDPI2023

Contrast-Enhanced Ultrasonography (CEUS) in Imaging of the Reproductive System in Dogs: A Literature Review.

Letizia Sinagra, Riccardo Orlandi, Tiziana Caspanello, Alessandro Troisi, Nicola Maria Iannelli, Emanuela Vallesi, Giorgia Pettina, Paolo Bargellini, Massimo De Majo, Cristiano Boiti and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Multimodal ultrasound assessment of ovarian reserve.Abdominal radiology (New York) · 2026
    Review
  2. Quantitative Parameters of Contrast-Enhanced Ultrasonography (CEUS) Monitoring Ovarian Hemodynamics in Rats.Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Letizia SinagraDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.
Riccardo OrlandiAnicura Tyrus Clinica Veterinaria, Via Bartocci 1G, 05100 Terni, Italy.
Tiziana CaspanelloDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.ORCID 0000-0003-1801-4454
Alessandro TroisiSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Macerata, Italy.ORCID 0000-0002-2192-6115
Nicola Maria IannelliDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.
Emanuela VallesiAnicura Tyrus Clinica Veterinaria, Via Bartocci 1G, 05100 Terni, Italy.ORCID 0000-0001-9853-4358
Giorgia PettinaDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.ORCID 0009-0001-2153-6731
Paolo BargelliniAnicura Tyrus Clinica Veterinaria, Via Bartocci 1G, 05100 Terni, Italy.
Massimo De MajoDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.ORCID 0000-0003-4527-7030
Cristiano BoitiTyrus Science Foundation, Via Bartocci 1G, 05100 Terni, Italy.
Santo CristarellaDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.ORCID 0000-0001-5909-7837
Marco QuartuccioDepartment of Veterinary Sciences, University of Messina, Viale Palatucci, 13, 98168 Messina, Italy.ORCID 0000-0002-4812-0402
Angela PoliscaDepartment of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
University of Messina · ITFondazione Audiologica Varese · ITUniversità di Camerino · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of contrast-enhanced ultrasound (CEUS) has been widely reported for reproductive imaging in humans and animals. This review aims to analyze the utility of CEUS in characterizing canine reproductive physiology and pathologies. In September 2022, a search for articles about CEUS in canine testicles, prostate, uterus, placenta, and mammary glands was conducted on PubMed and Scopus from 1990 to 2022, showing 36 total results. CEUS differentiated testicular abnormalities and neoplastic lesions, but it could not characterize tumors. In prostatic diseases, CEUS in dogs was widely studied in animal models for prostatic cancer treatment. In veterinary medicine, this diagnostic tool could distinguish prostatic adenocarcinomas. In ovaries, CEUS differentiated the follicular phases. In CEH-pyometra syndrome, it showed a different enhancement between endometrium and cysts, and highlighted angiogenesis. CEUS was shown to be safe in pregnant dogs and was able to assess normal and abnormal fetal-maternal blood flow and placental dysfunction. In normal mammary glands, CEUS showed vascularization only in diestrus, with differences between mammary glands. CEUS was not specific for neoplastic versus non-neoplastic masses and for benign tumors, except for complex carcinomas and neoplastic vascularization. Works on CEUS showed its usefulness in a wide spectrum of pathologies of this non-invasive, reliable diagnostic procedure.

Indexed as

CEUScontrast-enhanced ultrasounddiagnostic imagingdogmammary glandovaryprostatereproductiontestisuterus

Identifiers

PMID37238045
PMCPMC10215906
OpenAlexW4376279208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.