Evidence map›Paper›PMID 37237953›Full record

ArticleAntioxidants (Basel, Switzerland)2023

The Fate of Oxidative Strand Breaks in Mitochondrial DNA.

Genevieve Trombly, Afaf Milad Said, Alexei P Kudin, Viktoriya Peeva, Janine Altmüller, Kerstin Becker, Karl Köhrer, Gábor Zsurka, Wolfram S Kunz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Genevieve TromblyInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Afaf Milad SaidInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Alexei P KudinInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Viktoriya PeevaInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Janine AltmüllerCologne Center for Genomics and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, 50923 Köln, Germany.
Kerstin BeckerCologne Center for Genomics and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, 50923 Köln, Germany.
Karl KöhrerBiological and Medical Research Centre (BMFZ), Genomics & Transcriptomics Laboratory, Heinrich-Heine-University Duesseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-3644-2022
Gábor ZsurkaInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0002-6379-849X
Wolfram S KunzInstitute of Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, 53127 Bonn, Germany.ORCID 0000-0003-1113-3493
University of Bonn · DEUniversity of Cologne · DEHeinrich Heine University Düsseldorf · DE

Funding

Deutsche Forschungsgemeinschaft ZS 99/3-2 and ZS 99/4-1 to GZ, KU 911/21-2 and KU 911/22-1 to WSK.DFG Research Infrastructure West German Genome Center (407493903) as part of the Next Gen-eration Sequencing Competence Network (project 423957469).
6 · The paper itself

Abstract

Mitochondrial DNA (mtDNA) is particularly vulnerable to somatic mutagenesis. Potential mechanisms include DNA polymerase γ (POLG) errors and the effects of mutagens, such as reactive oxygen species. Here, we studied the effects of transient hydrogen peroxide (H

Indexed as

mitochondrial DNAmtDNA degradationmtDNA double-strand breaks mtDNA single-strand breaksoxidative damage

Identifiers

PMID37237953
PMCPMC10215735
OpenAlexW4378516394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.