Evidence map›Paper›PMID 37237946›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks.

Javier Ávila-Román, Patricia Gómez-Villegas, Carla C C R de Carvalho, Javier Vigara, Virginia Motilva, Rosa León, Elena Talero

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. A New Era for Using Natural Pigments: The Case of the CBiotechnology and applied biochemistry · 2026
    Review
  2. Recent Advances in Understanding Bio-Compounds from Haloarchaea.Journal of microbiology and biotechnology · 2026
    Review
  3. Article
  4. Bacterioruberin (CNutrients · 2025
    Review
  5. Article
  6. Phytochemical Analysis and Therapeutic Potential ofPlants (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Microbial Bacterioruberin: A Comprehensive Review.Indian journal of microbiology · 2024
    Review
  9. Halocins and CMarine drugs · 2024
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Javier Ávila-RománDepartment of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Profesor García González Street, 41012 Seville, Spain.ORCID 0000-0001-9766-8178
Patricia Gómez-VillegasLaboratory of Biochemistry, Center for Natural Resources, Health, and Environment, Universidad de Huelva, Avda. de las Fuerzas Armadas s/n, 21071 Huelva, Spain.ORCID 0000-0002-0511-8724
Carla C C R de CarvalhoiBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.ORCID 0000-0002-8142-3835
Javier VigaraLaboratory of Biochemistry, Center for Natural Resources, Health, and Environment, Universidad de Huelva, Avda. de las Fuerzas Armadas s/n, 21071 Huelva, Spain.ORCID 0000-0002-2617-5410
Virginia MotilvaDepartment of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Profesor García González Street, 41012 Seville, Spain.ORCID 0000-0001-5674-6969
Rosa LeónLaboratory of Biochemistry, Center for Natural Resources, Health, and Environment, Universidad de Huelva, Avda. de las Fuerzas Armadas s/n, 21071 Huelva, Spain.ORCID 0000-0002-6243-6454
Elena TaleroDepartment of Pharmacology, Faculty of Pharmacy, Universidad de Sevilla, Profesor García González Street, 41012 Seville, Spain.ORCID 0000-0001-9955-801X
Universidad de Sevilla · ESUniversidad de Huelva · ESUniversity of Lisbon · PT

Funding

Operative FEDER Program-Andalucía 2014-2020 UHU-1257518Operative FEDER Program-Andalucía 2014-2020 US-1380844Spanish Agencia Estatal de Investigación PID2019-110438RB-C22 -AEI/FEDERthe Andalusian government (I+D+i-JA-PAIDI-Retos projects 2020-PY20
6 · The paper itself

Abstract

The production of reactive oxygen species (ROS) plays an important role in the progression of many inflammatory diseases. The search for antioxidants with the ability for scavenging free radicals from the body cells that reduce oxidative damage is essential to prevent and treat these pathologies. Haloarchaea are extremely halophilic microorganisms that inhabit hypersaline environments, such as saltworks or salt lakes, where they have to tolerate high salinity, and elevated ultraviolet (UV) and infrared radiations. To cope with these extreme conditions, haloarchaea have developed singular mechanisms to maintain an osmotic balance with the medium, and are endowed with unique compounds, not found in other species, with bioactive properties that have not been fully explored. This study aims to assess the potential of haloarchaea as a new source of natural antioxidant and anti-inflammatory agents. A carotenoid-producing haloarchaea was isolated from Odiel Saltworks (OS) and identified on the basis of its 16S rRNA coding gene sequence as a new strain belonging to the genus

Indexed as

bacterioruberincarotenoidsfatty acidshaloarchaeainflammationmacrophagesOdiel Saltworksoxidative stress

Identifiers

PMID37237946
PMCPMC10215637
OpenAlexW4378516276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.