Evidence map›Paper›PMID 37237876›Full record

ArticleAntioxidants (Basel, Switzerland)2023

Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients.

Robert T Mankowski, Stephanie E Wohlgemuth, Guilherme Bresciani, A Daniel Martin, George Arnaoutakis, Tomas Martin, Eric Jeng, Leonardo Ferreira, Tiago Machuca, Mindaugas Rackauskas and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Robert T MankowskiDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32611, USA.
Stephanie E WohlgemuthDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32611, USA.
Guilherme BrescianiDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
A Daniel MartinDepartment of Physical Therapy, University of Florida, Gainesville, FL 32611, USA.
George ArnaoutakisDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Tomas MartinDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Eric JengDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Leonardo FerreiraDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0001-6581-5882
Tiago MachucaDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Mindaugas RackauskasDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Ashley J SmuderDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA.
Thomas BeaverDepartment of Surgery, University of Florida, Gainesville, FL 32611, USA.
Christiaan LeeuwenburghDepartment of Physiology and Aging, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-0826-4257
Barbara K SmithDepartment of Physical Therapy, University of Florida, Gainesville, FL 32611, USA.
University of Florida · US

Funding

Redox basis of diaphragm mitochondrial dysfunction and atrophy in heart failureR01HL130318 · NHLBI · UNIVERSITY OF FLORIDA · PI FERREIRA, LEONARDO · 2016 to 2025
$3.9M
The effect of intermittent hemidiaphragm stimulation during surgery on mitochondrial function, single fiber contractile force and catabolic pathways in humansR01AR072328 · NIAMS · UNIVERSITY OF FLORIDA · PI BEAVER, THOMAS M, SMITH, BARBARA K · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL130318NIH HHS R01 AR072328
6 · The paper itself

Abstract

Mechanical ventilation during cardiothoracic surgery is life-saving but can lead to ventilator-induced diaphragm dysfunction (VIDD) and prolong ventilator weaning and hospital length of stay. Intraoperative phrenic nerve stimulation may preserve diaphragm force production to offset VIDD; we also investigated changes in mitochondrial function after stimulation. During cardiothoracic surgeries (

Indexed as

biopsycardiothoracic surgerymitophagyrespirationVIDD

Identifiers

PMID37237876
PMCPMC10215949
OpenAlexW4367181646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.