ReviewAntioxidants (Basel, Switzerland)2023
Antioxidant and Anti-Inflammatory Properties of Walnut Constituents: Focus on Personalized Cancer Prevention and the Microbiome.
Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05195970 (Microbiota, Metabolites and Colon Neoplasia), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microbiota, Metabolites and Colon Neoplasia
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of Walnut (Juglans regia L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Pooled it
- Trial
- Trial
- Aroma and flavor profiling of walnut oils from five major Xinjiang cultivars: sensory evaluation and comparative analysis.Food chemistry: X · 2026Article
- An Untargeted Metabolomic Approach to Characterize the Emerging Kernel Disorder "Orange Spot" in Walnut (Metabolites · 2026Article
- Effects of Walnut Consumption on Blood Lipid Profile and Apolipoproteins in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of 49 Randomized Controlled Trials.Food science & nutrition · 2026Review
- Yield and Quality of Walnuts Subjected to Deficit Irrigation in Mountainous Water-Starved Environments.Plants (Basel, Switzerland) · 2025Article
- Systemic Inflammation and the Inflammatory Context of the Colonic Microenvironment Are Improved by Urolithin A.Cancer prevention research (Philadelphia, Pa.) · 2025Article
- Chemical Analysis and Antioxidant Activities of Resin Fractions fromMolecules (Basel, Switzerland) · 2025Article
- The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial.Nutrition & metabolism · 2025Article
- Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine.Nanotheranostics · 2025Review
- The Phytochemical Profile of the Petroleum Ether Extract ofInternational journal of molecular sciences · 2024Article
- Correlation between intestinal microbiota and urolithin metabolism in a human walnut dietary intervention.BMC microbiology · 2024Article
- Integrated Transcriptomic and Proteomic Analysis of Nutritional Quality-Related Molecular Mechanisms in "Longjia", "Yangpao", and "Niangqing" Walnuts (International journal of molecular sciences · 2024Article
- Mechanistic Insights into the Biological Effects and Antioxidant Activity of Walnut (Antioxidants (Basel, Switzerland) · 2024Review
- Walnut oil: a promising nutraceutical in reducing oxidative stress and improving cholinergic activity in anToxicology research · 2024Article
- Comparative Study of Different Walnut (Plants (Basel, Switzerland) · 2024Article
- Transcriptomic Analyses Reveal the Effects of Walnut Kernel Cake on Adipose Deposition in Pigs.Genes · 2024Article
- The Antitumor Effects of α-Linolenic Acid.Journal of personalized medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Walnuts have been lauded as a 'superfood', containing a remarkable array of natural constituents that may have additive and/or synergistic properties that contribute to reduced cancer risk. Walnuts are a rich source of polyunsaturated fatty acids (PUFAs: alpha-linolenic acid, ALA), tocopherols, antioxidant polyphenols (including ellagitannins), and prebiotics, including fiber (2 g/oz). There is a growing body of evidence that walnuts may contribute in a positive way to the gut microbiome, having a prebiotic potential that promotes the growth of beneficial bacteria. Studies supporting this microbiome-modifying potential include both preclinical cancer models as well as several promising human clinical trials. Mediated both directly and indirectly via its actions on the microbiome, many of the beneficial properties of walnuts are related to a range of anti-inflammatory properties, including powerful effects on the immune system. Among the most potent constituents of walnuts are the ellagitannins, primarily pedunculagin. After ingestion, the ellagitannins are hydrolyzed at low pH to release ellagic acid (EA), a non-flavonoid polyphenolic that is subsequently metabolized by the microbiota to the bioactive urolithins (hydroxydibenzo[b,d]pyran-6-ones). Several urolithins, including urolithin A, reportedly have potent anti-inflammatory properties. These properties of walnuts provide the rationale for including this tree nut as part of a healthy diet for reducing overall disease risk, including colorectal cancer. This review considers the latest information regarding the potential anti-cancer and antioxidant properties of walnuts and how they may be incorporated into the diet to provide additional health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.