ArticleAntibiotics (Basel, Switzerland)2023
Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.
Article in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Case Report: A rare culprit of severe pulmonary infection in children: prevotella.Frontiers in pediatrics · 2026Article
- Effect of preoperative antibiotic use on the implant success rate: a retrospective cohort study of cefixime and ornidazole in China.BMC oral health · 2025Article
- Whole-genome sequencing and genomic analysis of fourFrontiers in microbiology · 2024Article
- Distribution, Trends, and Antimicrobial Susceptibility ofOpen forum infectious diseases · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAnaerobic Gram-negative bacteria (AGNB) play a significant role as both pathogens and essential members of the human microbiota. Despite their clinical importance, there remains limited understanding regarding their antimicrobial resistance (AMR) patterns. This knowledge gap poses challenges in effectively managing AGNB-associated infections, as empirical treatment approaches may not adequately address the evolving resistance landscape. To bridge this research gap, we conducted a comprehensive study aimed at exploring the role of human AGNB as a reservoir of AMR. This can provide valuable insights for the prevention and management of anaerobic infections.
methodsWe studied the prevalence of AMR and AMR determinants conferring resistance to metronidazole (
resultsResistance to metronidazole, clindamycin, imipenem, piperacillin-tazobactam, cefoxitin and chloramphenicol was 29%, 33.5%, 0.5%, 27.5%, 26.5% and 0%, respectively. The presence of resistance genes, viz.,
conclusionAGNB acts as a reservoir of specific AMR genes, which may pose a threat to other anaerobes due to functional compatibility and acquisition of these genes. Thus, AST-complying standard guidelines must be performed periodically to monitor the local and institutional susceptibility trends, and rational therapeutic strategies must be adopted to direct empirical management.
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