Evidence map›Paper›PMID 37237842›Full record

ReviewAntibiotics (Basel, Switzerland)2023

From Gene to Transcript and Peptide: A Deep Overview on Non-Specific Lipid Transfer Proteins (nsLTPs).

Carlos André Dos Santos-Silva, José Ribamar Costa Ferreira-Neto, Vinícius Costa Amador, João Pacífico Bezerra-Neto, Lívia Maria Batista Vilela, Eliseu Binneck, Mireli de Santana Rêgo, Manassés Daniel da Silva, Ana Luiza Trajano Mangueira de Melo, Rahisa Helena da Silva and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Peptide hormones in plants.Molecular horticulture · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Carlos André Dos Santos-SilvaInstitute for Maternal and Child Health-IRCCS Burlo Garofolo, 34137 Trieste, Italy.
José Ribamar Costa Ferreira-NetoDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0003-0935-203X
Vinícius Costa AmadorDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-7946-5665
João Pacífico Bezerra-NetoInstituto de Ciências Biológicas, Universidade de Pernambuco, Recife 50100-010, Brazil.ORCID 0000-0003-3861-4879
Lívia Maria Batista VilelaDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Eliseu BinneckEmpresa Brasileira de Pesquisa Agropecuária, Embrapa Soja, Londrina 86085-981, Brazil.ORCID 0000-0002-0942-0437
Mireli de Santana RêgoDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Manassés Daniel da SilvaDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0002-3316-8024
Ana Luiza Trajano Mangueira de MeloDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.ORCID 0000-0003-3306-5110
Rahisa Helena da SilvaDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Ana Maria Benko-IsepponDepartamento de Genética, Centro de Biociências, Universidade Federal de Pernambuco, Recife 50670-901, Brazil.
Universidade Federal de Pernambuco · BRBrazilian Agricultural Research Corporation · BRIRCCS Materno Infantile Burlo Garofolo · ITUniversidade de Pernambuco · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88881.507105/2020-01Fundação de Amparo à Ciência e Tecnologia de Pernambuco BFP-0021-21-57015National Council for Scientific and Technological Development 406048/2022-3, 313581/2020-7, 442019/2019-0, and 433931/2018-3
6 · The paper itself

Abstract

Non-specific lipid transfer proteins (nsLTPs) stand out among plant-specific peptide superfamilies due to their multifaceted roles in plant molecular physiology and development, including their protective functions against pathogens. These antimicrobial agents have demonstrated remarkable efficacy against bacterial and fungal pathogens. The discovery of plant-originated, cysteine-rich antimicrobial peptides such as nsLTPs has paved the way for exploring the mentioned organisms as potential biofactories for synthesizing antimicrobial compounds. Recently, nsLTPs have been the focus of a plethora of research and reviews, providing a functional overview of their potential activity. The present work compiles relevant information on nsLTP omics and evolution, and it adds meta-analysis of nsLTPs, including: (1) genome-wide mining in 12 plant genomes not studied before; (2) latest common ancestor analysis (LCA) and expansion mechanisms; (3) structural proteomics, scrutinizing nsLTPs' three-dimensional structure/physicochemical characteristics in the context of nsLTP classification; and (4) broad nsLTP spatiotemporal transcriptional analysis using soybean as a study case. Combining a critical review with original results, we aim to integrate high-quality information in a single source to clarify unexplored aspects of this important gene/peptide family.

Indexed as

expansion mechanismsgene expressiongenomicslast common ancestorplant stress

Identifiers

PMID37237842
PMCPMC10215178
OpenAlexW4377289766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.