Evidence map›Paper›PMID 37237671›Full record

ReviewBioengineering (Basel, Switzerland)2023

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.

Antonia van Kampen, Jordan E Morningstar, Guillaume Goudot, Neil Ingels, Jonathan F Wenk, Yasufumi Nagata, Koushiar M Yaghoubian, Russell A Norris, Michael A Borger, Serguei Melnitchouk and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonia van KampenDivision of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-4412-6337
Jordan E MorningstarDepartment of Regenerative Medicine and Cell Biology, University of South Carolina, Charleston, SC 29425, USA.
Guillaume GoudotCardiac Ultrasound Laboratory, Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Neil IngelsDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.
Jonathan F WenkDepartment of Mechanical Engineering, University of Kentucky, Lexington, KY 40508, USA.
Yasufumi NagataCardiac Ultrasound Laboratory, Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Koushiar M YaghoubianDivision of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Russell A NorrisDepartment of Regenerative Medicine and Cell Biology, University of South Carolina, Charleston, SC 29425, USA.
Michael A BorgerLeipzig Heart Centre, University Clinic of Cardiac Surgery, 02189 Leipzig, Germany.
Serguei MelnitchoukDivision of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Robert A LevineCardiac Ultrasound Laboratory, Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Morten O JensenDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.

Funding

Improving Mitral Compensation In Ischemic RegurgitationR01HL141917 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AIKAWA, ELENA, BISCHOFF, JOYCE E. · 2018 to 2021
$5.6M
Cilia and Valvular Heart DiseaseR01HL131546 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2016 to 2025
$4.4M
Dzip1 and Mitral Valve ProlapseR01HL149696 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NORRIS, RUSSELL · 2020 to 2023
$2.0M
Biomechanical Stimulation of Hemogenic Endothelial Cells to Develop Clinical-Grade Hematopoietic Stem CellsR01HL131645 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI SHAH, DHVANIT INDRAVADAN · 2016 to 2019
$1.6M
Force Validated Heart Valve Surgical Planning ToolR15HL145585 · NHLBI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI JENSEN, MORTEN OLGAARD · 2019 to 2019
$417k
Mechanisms of Left Ventricular Fibrosis in Mitral Valve ProlapseF31HL167482 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MORNINGSTAR, JORDAN E. · 2023 to 2024
$55k
NHLBI NIH HHS F31 HL167482NHLBI NIH HHS R01 HL131546NHLBI NIH HHS R01 HL131645NHLBI NIH HHS R01 HL141917NHLBI NIH HHS R01 HL149696NHLBI NIH HHS R15 HL145585NIH HHS 1F31HL167482NIH HHS 1R01GM10344NIH HHS 1R01HL131645NIH HHS 1R01HL141917NIH HHS 1R01HL149696NIH HHS 1R15HL145585
6 · The paper itself

Abstract

The geometrical details and biomechanical relationships of the mitral valve-left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

Indexed as

biomechanicscomputational modellingex vivo modellingforce measurementsmechanical engineeringmitral valvemitral valve simulationsubvalvular apparatus

Identifiers

PMID37237671
PMCPMC10215167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.