Evidence map›Paper›PMID 37237647›Full record

ArticleBioengineering (Basel, Switzerland)2023

Non-Invasive Hybrid Ultrasound Stimulation of Visual Cortex In Vivo.

Chen Gong, Runze Li, Gengxi Lu, Jie Ji, Yushun Zeng, Jiawen Chen, Chifeng Chang, Junhang Zhang, Lily Xia, Deepthi S Rajendran Nair and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Neural Vision Restoration in Ophthalmology.Annals of biomedical engineering · 2026
    Review
  2. Article
  3. A flexible photoacoustic retinal prosthesis.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Chen GongDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-6262-704X
Runze LiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-6642-5904
Gengxi LuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-7497-050X
Jie JiDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Yushun ZengDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-5995-4085
Jiawen ChenDepartment of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.
Chifeng ChangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Junhang ZhangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Lily XiaDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Deepthi S Rajendran NairUSC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Biju B ThomasUSC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Brian J SongUSC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0003-4226-3135
Mark S HumayunDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Qifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
University of Southern California · US

Funding

Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
High Resolution Elastograpy of Retina Under Prosthetic Electrical StimulationR01EY026091 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, ZHOU, QIFA · 2016 to 2019
$2.0M
Non-invasive Ultrasound Stimulated Retinal ProsthesisR01EY030126 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZHOU, QIFA · 2019 to 2022
$2.0M
NEI NIH HHS P30 EY029220NEI NIH HHS P30EY029220NEI NIH HHS R01 EY026091NEI NIH HHS R01 EY028662NEI NIH HHS R01 EY030126
6 · The paper itself

Abstract

The optic nerve is the second cranial nerve (CN II) that connects and transmits visual information between the retina and the brain. Severe damage to the optic nerve often leads to distorted vision, vision loss, and even blindness. Such damage can be caused by various types of degenerative diseases, such as glaucoma and traumatic optic neuropathy, and result in an impaired visual pathway. To date, researchers have not found a viable therapeutic method to restore the impaired visual pathway; however, in this paper, a newly synthesized model is proposed to bypass the damaged portion of the visual pathway and set up a direct connection between a stimulated visual input and the visual cortex (VC) using Low-frequency Ring-transducer Ultrasound Stimulation (LRUS). In this study, by utilizing and integrating various advanced ultrasonic and neurological technologies, the following advantages are achieved by the proposed LRUS model: 1. This is a non-invasive procedure that uses enhanced sound field intensity to overcome the loss of ultrasound signal due to the blockage of the skull. 2. The simulated visual signal generated by LRUS in the visual-cortex-elicited neuronal response in the visual cortex is comparable to light stimulation of the retina. The result was confirmed by a combination of real-time electrophysiology and fiber photometry. 3. VC showed a faster response rate under LRUS than light stimulation through the retina. These results suggest a potential non-invasive therapeutic method for restoring vision in optic-nerve-impaired patients using ultrasound stimulation (US).

Indexed as

electrophysiologynon-invasiveoptic nerve damagephotometryultrasound stimulationvision restorationvisual cortex

Identifiers

PMID37237647
PMCPMC10215307
OpenAlexW4378516162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.