ArticleBioengineering (Basel, Switzerland)2023
Virtual Joint Motion Simulator Accurately Predicts Effects of Femoral Component Malalignment during TKA.
Article in Bioengineering (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Digital Twins in Orthopedics and Trauma: Concepts, Emerging Evidence, and Barriers to Clinical Translation.Journal of clinical medicine · 2026Review
- Artificial intelligence in orthopaedics: Enhanced examinations, ambient intelligence and the future of clinical practice.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Review
- Methodology for biomechanical investigation of implant malpositioning in total knee arthroplasty using a six degree of freedom joint simulator.Arthroplasty (London, England) · 2025Article
- Muscle-Driven Total Knee Replacement Stability with Virtual Ligaments.Bioengineering (Basel, Switzerland) · 2025Article
- Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review.Journal of medical Internet research · 2024Article
- Exploration of the Advanced VIVOBioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Component alignment accuracy during total knee arthroplasty (TKA) has been improving through the adoption of image-based navigation and robotic surgical systems. The biomechanical implications of resulting component alignment error, however, should be better characterized to better understand how sensitive surgical outcomes are to alignment error. Thus, means for analyzing the relationships between alignment, joint kinematics, and ligament mechanics for candidate prosthesis component design are necessary. We used a digital twin of a commercially available joint motion simulator to evaluate the effects of femoral component rotational alignment. As anticipated, the model showed that an externally rotated femoral component results in a knee which is more varus in flexion, with lower medial collateral ligament tension compared to a TKA knee with a neutrally aligned femoral implant. With the simulation yielding logical results for this relatively simple test scenario, we can have more confidence in the accuracy of its predictions for more complicated scenarios.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.