Evidence map›Paper›PMID 37237468›Full record

ArticleBiology2023

Prenatal Exposition to Different Immunosuppressive Protocols Results in Vacuolar Degeneration of Hepatocytes.

Aleksandra Wilk, Dagmara Szypulska-Koziarska, Dorota Oszutowska-Mazurek, Alexander Baraniskin, Joanna Kabat-Koperska, Przemyslaw Mazurek, Barbara Wiszniewska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Aleksandra WilkDepartment of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-1542-8371
Dagmara Szypulska-KoziarskaDepartment of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-7392-7902
Dorota Oszutowska-MazurekDepartment of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0001-6403-4160
Alexander BaraniskinDepartment of Hematology, Oncology and Palliative Care, Evangelisches Krankenhaus Hamm, 59063 Hamm, Germany.ORCID 0000-0002-0408-1552
Joanna Kabat-KoperskaDepartment of Nephrology, Transplantology and Internal Diseases, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0003-4768-1643
Przemyslaw MazurekDepartment of Signal Processing and Multimedia Engineering, West Pomeranian University of Technology in Szczecin, 71-126 Szczecin, Poland.ORCID 0000-0002-7145-3993
Barbara WiszniewskaDepartment of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.ORCID 0000-0002-9064-6969
Pomeranian Medical University · PLEvangelisches Krankenhaus Hamm · DEWest Pomeranian University of Technology in Szczecin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunosuppressive drugs are essential for transplant recipients, since they prolong proper function of graft; however, they affect the morphology and function of organs, including liver. One commonly observed alteration in hepatocytes is vacuolar degeneration. Numerous medications are contraindicated in pregnancy and breastfeeding, mostly due to a lack of data concerning their advert effects. The aim of the current study was to compare the effects of prenatal exposition to different protocols of immunosuppressants on vacuolar degeneration in the hepatocytes of livers of rats. Thirty-two livers of rats with usage of digital analysis of the images were examined. Area, perimeter, axis length, eccentricity and circularity regarding vacuolar degeneration were analysed. The most prominent vacuolar degeneration in hepatocytes in the aspects of presence, area and perimeter was observed in rats exposed to tacrolimus, mycophenolate mofetil and glucocorticoids, and cyclosporine A, everolimus with glucocorticoids.This is the first study that demonstrates the results of the influence of multidrug immnunosuppression distributed in utero on the hepatic tissue of offspring.

Indexed as

image analysisimmunosuppressive drugslivermorphologyvacuolar degeneration

Identifiers

PMID37237468
PMCPMC10215157
OpenAlexW4367182188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.