Evidence map›Paper›PMID 37237248›Full record

ReviewHuman cell2023

From in vivo to in vitro: exploring the key molecular and cellular aspects of human female gametogenesis.

Sarah Abreu Coxir, Guilherme Mattos Jardim Costa, Camilla Fernandes Dos Santos, Raquel de Lima Leite Soares Alvarenga, Samyra Maria Dos Santos Nassif Lacerda

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Reporter Alleles in hiPSCs: Visual Cues on Development and Disease.International journal of molecular sciences · 2024
    Review
  4. Review
  5. The regulatory roles of Smad2/3 protein andInternational journal of reproductive biomedicine · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah Abreu CoxirLaboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Guilherme Mattos Jardim CostaLaboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Camilla Fernandes Dos SantosLaboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Raquel de Lima Leite Soares AlvarengaClínica Cegonha de Medicina Reprodutiva, Belo Horizonte, MG, 30160-030, Brazil.
Samyra Maria Dos Santos Nassif LacerdaLaboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. samyranassif@ufmg.br.ORCID http://orcid.org/0000-0003-4577-6243
Universidade Federal de Minas Gerais · BRInstituto Tropical de Medicina Reprodutiva · BR

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00079-22Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00135-22
6 · The paper itself

Abstract

Human oogenesis is a highly complex and not yet fully understood process due to ethical and technological barriers that limit studies in the field. In this context, replicating female gametogenesis in vitro would not only provide a solution for some infertility problems, but also be an excellent study model to better understand the biological mechanisms that determine the formation of the female germline. In this review, we explore the main cellular and molecular aspects involved in human oogenesis and folliculogenesis in vivo, from the specification of primordial germ cells (PGCs) to the formation of the mature oocyte. We also sought to describe the important bidirectional relationship between the germ cell and the follicular somatic cells. Finally, we address the main advances and different methodologies used in the search for obtaining cells of the female germline in vitro.

Indexed as

GametogenesisOogenesisGerm CellsHumansArtificial gametesFemale germ cellsGranulosa cellsHuman oogenesisOvarian somatic cellsPrimordial germ cells

Identifiers

PMID37237248
OpenAlexW4378374546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.