Evidence map›Paper›PMID 37237052›Full record

ArticleCommunications biology2023

Fatigue-driven compliance increase and collagen unravelling in mechanically tested anterior cruciate ligament.

Kevin H Putera, Jinhee Kim, So Young Baek, Stephen H Schlecht, Mélanie L Beaulieu, Victoria Haritos, Ellen M Arruda, James A Ashton-Miller, Edward M Wojtys, Mark M Banaszak Holl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Female Anterior Cruciate Ligaments Exhibit a Muted Mechanobiological Response to Mechanical Loading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  6. Review
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kevin H PuteraDepartment of Chemical and Biological Engineering, Monash University, Clayton, VIC, 3800, Australia.ORCID 0000-0001-9447-6883
Jinhee KimDepartment of Chemical and Biological Engineering, Monash University, Clayton, VIC, 3800, Australia.
So Young BaekDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
Stephen H SchlechtDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-6857-927X
Mélanie L BeaulieuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-0333-5514
Victoria HaritosDepartment of Chemical and Biological Engineering, Monash University, Clayton, VIC, 3800, Australia.ORCID 0000-0003-4630-9647
Ellen M ArrudaDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.
James A Ashton-MillerDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-1528-2787
Edward M WojtysDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Mark M Banaszak HollDepartment of Chemical and Biological Engineering, Monash University, Clayton, VIC, 3800, Australia. mmbanasz@uab.edu.ORCID 0000-0001-7759-7456
University of Michigan · USMonash University · AUIndiana University School of MedicineUniversity of Alabama at Birmingham Hospital · US

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
New Perspectives on ACL InjuryR01AR054821 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ASHTON-MILLER, JAMES ANTHONY, WOJTYS, EDWARD M · 2007 to 2021
$3.1M
NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR054821
6 · The paper itself

Abstract

Approximately 300,000 anterior cruciate ligament (ACL) tears occur annually in the United States, half of which lead to the onset of knee osteoarthritis within 10 years of injury. Repetitive loading is known to result in fatigue damage of both ligament and tendon in the form of collagen unravelling, which can lead to structural failure. However, the relationship between tissue's structural, compositional, and mechanical changes are poorly understood. Herein we show that repetitive submaximal loading of cadaver knees causes an increase in co-localised induction of collagen unravelling and tissue compliance, especially in regions of greater mineralisation at the ACL femoral enthesis. Upon 100 cycles of 4× bodyweight knee loading, the ACL exhibited greater unravelled collagen in highly mineralized regions across varying levels of stiffness domains as compared to unloaded controls. A decrease in the total area of the most rigid domain, and an increase in the total area of the most compliant domain was also found. The results highlight fatigue-driven changes in both protein structure and mechanics in the more mineralized regions of the ACL enthesis, a known site of clinical ACL failure. The results provide a starting point for designing studies to limit ligament overuse injury.

Indexed as

Anterior Cruciate LigamentAnterior Cruciate Ligament InjuriesBiomechanical PhenomenaCollagenFatigueHumansKnee JointCollagen

Identifiers

PMID37237052
PMCPMC10219950
OpenAlexW4378471845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.