SynthesisNature communications2023
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
Registry-linked trialOpen access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383454 (Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model), which is not on this map. Cited by 59 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 5 pooled it
16.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model
Who cites it
59 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Development and validation of a multiancestry and multitrait polygenic risk score for lung cancer.Nature communications · 2026Pooled it
- Genome-wide meta-analysis across East Asian and European populations provides insights into the molecular basis of lung cancer.Genome medicine · 2026Pooled it
- The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank.British journal of cancer · 2026Pooled it
- Circulating proteins associated with histological subtypes of lung cancer from genetic and population-based perspectives.PLoS genetics · 2025Pooled it
- Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.Nature communications · 2024Pooled it
- Prevalence and Clinical Implications of Somatic and Germline EGFR Mutations in Patients with Non-Small-Cell Lung Cancer.Cancers · 2026Review
- EpiSNPdb: A Comprehensive Database of Genetic Epistasis Across Multiple Cancer Types.Current issues in molecular biology · 2026Article
- Molecules of lung cancer - fusion alterations in nonsmall cell lung cancer: biology and diagnostic considerations.Breathe (Sheffield, England) · 2026Review
- Identifying expression and DNA methylation biomarkers for lung adenocarcinoma risk in East Asia.Journal of the National Cancer Institute · 2026Article
- H4K8 lactylation-mediated ferroptosis defense drives EGFR-TKI resistance in lung adenocarcinoma.Apoptosis : an international journal on programmed cell death · 2026Article
- SPOCK1 acts as a negative regulator of ferroptosis in non-small cell lung cancer.NPJ precision oncology · 2026Article
- Innovative approaches for lung cancer screening and interception.Nature reviews. Clinical oncology · 2026Review
- A new era of precision diagnosis and treatment for lung cancer: artificial intelligence-driven multimodal data integration and clinical applications.Cell death & disease · 2026Review
- Article
- Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression.bioRxiv : the preprint server for biology · 2026Article
- Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology.bioRxiv : the preprint server for biology · 2026Article
- Machine learning-based proteogenomic data modeling identifies circulating plasma biomarkers for early detection of lung cancer.Communications medicine · 2026Article
- Single-cell eQTL mapping reveals cell-type-specific genetic regulation in lung cancer.Cell genomics · 2026Article
- Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus.medRxiv : the preprint server for health sciences · 2026Article
- Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.Nature genetics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
222 authors at 20 institutions in 19 countries.
Jianxin Shi *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. jianxin.shi@nih.gov.ORCID 0000-0001-8606-4707
Kouya Shiraishi *Division of Genome Biology, National Cancer Research Institute, Tokyo, Japan.ORCID 0000-0002-5821-7400
Jiyeon Choi *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-0955-2384
Keitaro Matsuo *Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Tzu-Yu Chen *Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0002-0146-3782
Juncheng Dai *Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-3909-5671
Rayjean J Hung *Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, ON, Canada.ORCID 0000-0002-4486-7496
Kexin Chen *Department of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Xiao-Ou Shu *Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Young Tae KimCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID 0000-0001-9006-4881
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Dongxin LinDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.ORCID 0000-0003-1226-070X
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Baosen ZhouDepartment of Clinical Epidemiology and Center of Evidence Based Medicine, The First Hospital of China Medical University, Shenyang, China.ORCID 0000-0002-5311-3880
Bao SongDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Jiucun WangMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.ORCID 0000-0003-2765-0620
Wei Jie SeowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Lei SongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
I-Shou ChangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0002-6254-8114
Wei HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Li-Hsin ChienInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.ORCID 0000-0002-9384-5648
Yun-Chul HongDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Hee Nam KimDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Yi-Long WuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID 0000-0002-3611-0258
Maria Pik WongDepartment of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.
Brian Douglas RichardsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Karen M FunderburkDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Shilan LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0003-2124-2706
Charles BreezeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Zhaoming WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7556-3869
Batel BlechterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jin Hee KimDepartment of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-8330-4293
Jason Y Y WongDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.ORCID 0000-0002-2217-5624
Lap Ping ChungDepartment of Pathology, Queen Mary Hospital, Hong Kong, Hong Kong.
Yang YangShanghai Pulmonary Hospital, Shanghai, China.
She-Juan AnGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Hong ZhengDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Yasushi YatabeDepartment of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.
Xu-Chao ZhangGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID 0000-0002-4138-8115
Young-Chul KimLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jiang ChangDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
James Chung Man HoDepartment of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.ORCID 0000-0003-4499-5284
Michiaki KuboLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-0095-2322
Yataro DaigoCenter for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Minsun SongDepartment of Statistics & Research Institute of Natural Sciences, Sookmyung Women's University, Seoul, Republic of Korea.
Yukihide MomozawaLaboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-8748-5597
Masashi KobayashiDepartment of Thoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Kenichi OkuboDepartment of Thoracic Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Takayuki HondaDepartment of Respiratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Dean H HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
Hideo KunitohDepartment of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan.
Harsh PatelDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-9860-8254
Shun-Ichi WatanabeDepartment of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yohei MiyagiMolecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan.ORCID 0000-0002-0056-7010
Haruhiko NakayamaDepartment of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Shingo MatsumotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Hidehito HorinouchiDepartment of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.ORCID 0000-0001-9090-801X
Masahiro TsuboiDepartment of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Ryuji HamamotoDivision of Medical AI Research and Development, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-2632-1334
Koichi GotoDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.ORCID 0000-0002-3023-2510
Yuichiro OheDepartment of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0001-7099-8767
Akiteru GotoDepartment of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.
Yoshihiro MinamiyaDepartment of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita, Japan.
Megumi HaraDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.ORCID 0000-0002-8708-3237
Yuichiro NishidaDepartment of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.ORCID 0000-0003-2320-7234
Kenji TakeuchiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Koichi MatsudaLaboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7292-2686
Yoshinori MurakamiDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-2826-4396
Kimihiro ShimizuDepartment of Surgery, Division of General Thoracic Surgery, Shinshu University School of Medicine Asahi, Nagano, Japan.ORCID 0000-0003-4076-5174
Hiroyuki SuzukiDepartment of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Motonobu SaitoDepartment of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID 0000-0001-5072-3520
Yoichi OhtakiDepartment of Integrative center of General Surgery, Gunma University Hospital, Gunma, Japan.ORCID 0000-0001-5485-3234
Kazumi TanakaDepartment of Integrative center of General Surgery, Gunma University Hospital, Gunma, Japan.
Tangchun WuInstitute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0001-9931-5106
Fusheng WeiChina National Environmental Monitoring Center, Beijing, China.
Hongji DaiDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-6538-9705
Jian SuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yeul Hong KimDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.ORCID 0000-0002-2555-2333
In-Jae OhLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasuneup, Republic of Korea.ORCID 0000-0003-4837-1321
Victor Ho Fun LeeDepartment of Clinical Oncology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.ORCID 0000-0002-6283-978X
Gee-Chen ChangSchool of Medicine and Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Ying-Huang TsaiDepartment of Respiratory Therapy, Chang Gung University, Taoyuan, Taiwan.
Kuan-Yu ChenDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Ming-Shyan HuangDepartment of Internal Medicine, E-Da Cancer Hospital, I-Shou University and Kaohsiung Medical University, Kaohsiung, Taiwan.
Wu-Chou SuDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Yuh-Min ChenDepartment of Chest Medicine, Taipei Veterans General Hospital, and school of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Adeline SeowSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Jae Yong ParkLung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Kun-Chieh ChenDepartment of Internal Medicine, Division of Pulmonary Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Biyun QianDepartment of Epidemiology and Biostatistics, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, China.
Chen WuDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Jianjun LiuGenome Institute of Singapore, Agency of Science, Technology and Research, Singapore, Singapore.ORCID 0000-0002-3255-3019
Ann G SchwartzKarmanos Cancer Institute, Detroit, MI, USA.
Richard HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.ORCID 0000-0002-5268-0242
Margaret R SpitzDepartment of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.
Ivan P GorlovDepartment of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.
Xifeng WuSchool of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.ORCID 0000-0003-2980-8129
Ping YangDepartment of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA.
Stephen LamBritish Columbia Cancer Agency, Vancouver, BC, Canada.
Adonina TardonIUOPA, University of Oviedo and CIBERESP, Madrid, Spain.ORCID 0000-0001-5150-1209
Chu ChenPublic Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Stig E BojesenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4061-4133
Mattias JohanssonInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.ORCID 0000-0002-3116-5081
Angela RischGerman Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8026-5505
Heike BickeböllerUniversity Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0002-3361-5488
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
H-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany.
David C ChristianiHarvard TH Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-0301-0242
Gadi RennertCarmel Medical Center, Haifa, Israel.ORCID 0000-0002-8512-068X
Susanne ArnoldMarkey Cancer Center, Lexington, KY, USA.ORCID 0000-0001-6542-9551
Paul BrennanInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
James McKayInternational Agency for Research on Cancer (IARC/WHO), Lyon, France.
John K FieldLiverpool University, Liverpool, UK.ORCID 0000-0003-3951-6365
Sanjay S SheteThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7622-376X
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Geoffrey LiuPrincess Margaret Cancer Center, Toronto, ON, Canada.
Angeline AndrewNorris Cotton Cancer Center, Lebanon, NH, USA.
Lambertus A KiemeneyRadboud University Medical Center, Nijmegen, Netherlands.ORCID 0000-0002-2368-1326
Shan Zienolddiny-NaruiNational Institute of Occupational Health, Oslo, Norway.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.ORCID 0000-0003-4289-2097
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.ORCID 0000-0003-4182-8923
Angela CoxUniversity of Sheffield, Sheffield, UK.ORCID 0000-0002-5138-1099
Fiona TaylorUniversity of Sheffield, Sheffield, UK.
Jian-Min YuanUPMC Hillman Cancer Center and Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4620-3108
Philip LazarusWashington State University College of Pharmacy, Spokane, WA, USA.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID 0000-0003-3241-3216
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Hyo-Sung JeonCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Shih Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
Jae Sook SungDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Chung-Hsing ChenNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0002-1205-7368
Chin-Fu HsiaoInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Yoo Jin JungDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Huan GuoDepartment of Occupational and Environmental Health and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhibin HuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-8277-5234
Laurie BurdettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-8014-4888
Jia LiuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Wei WuDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Junwen WangDepartment of Biochemistry, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Yuqing LiDepartment of Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Jin Eun ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Kyong Hwa ParkDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Sook Whan SungDepartment of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Li LiuDepartment of Oncology, Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Chang Hyun KangDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Wen-Chang WangThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Wen TanDepartment of Etiology & Carcinogenesis and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chong-Jen YuDepartment of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.ORCID 0000-0001-5664-9392
Gong YangDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Alan Dart Loon SihoeGleneagles Hong Kong Hospital, Hong Kong, China.
Ying ChenSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Yi Young ChoiCancer Research Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Jun Suk KimDepartment of Internal Medicine, Division of Medical Oncology, College of Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
Ho-Il YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
In Kyu ParkDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ping XuDepartment of Oncology, Wuhan Iron and Steel (Group) Corporation Staff-Worker Hospital, Wuhan, China.
Qincheng HeDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Chih-Liang WangDepartment of Pulmonary and Critical Care, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hsiao-Han HungNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0002-5466-4828
Roel C H VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
Iona ChengDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Junjie WuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Wei-Yen LimSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan.
John K C ChanDepartment of Pathology, Queen Elizabeth Hospital, Hong Kong, China.ORCID 0000-0001-5068-6707
Jihua LiQujing Center for Diseases Control and Prevention, Qujing, China.
Hongyan ChenMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Hsien-Chih LinInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.
Li JinMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
Jie LiuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Norie SawadaDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.ORCID 0000-0002-9936-1476
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Kathleen WyattDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Shengchao A LiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0001-9252-1492
Hongxia MaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Meng ZhuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Zhehai WangDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Sensen ChengDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Xuelian LiDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Yangwu RenDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Ann ChaoCenter for Global Health, National Cancer Institute, Bethesda, MD, USA.
Motoki IwasakiDivision of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Junjie ZhuShanghai Pulmonary Hospital, Shanghai, China.
Gening JiangShanghai Pulmonary Hospital, Shanghai, China.
Ke FeiShanghai Pulmonary Hospital, Shanghai, China.
Guoping WuChina National Environmental Monitoring Center, Beijing, China.
Chih-Yi ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chien-Jen ChenGenomic Research Center, Academia Sinica, Taipei, Taiwan.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0001-6330-6048
Jinming YuDepartment of Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.
Victoria L StevensLaboratory Services, American Cancer Society, Atlanta, GA, USA.ORCID 0000-0003-0259-4407
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Olga Y GorlovaDepartment of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.
Chao Agnes HsiungInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan.ORCID 0000-0003-1427-6641
Christopher I AmosDepartment of Medicine, Section of Epidemiology and Population Science, Institute for Clinical and Translational Research, Houston, TX, USA.ORCID 0000-0002-8540-7023
Hongbing ShenDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID 0000-0002-2581-5906
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Takashi KohnoDivision of Genome Biology, National Cancer Research Institute, Tokyo, Japan.ORCID 0000-0002-5371-706X
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. qingl@mail.nih.gov.ORCID 0000-0002-0888-8839
National Cancer Institute · USNational Health Research Institutes · TWLeidos (United States) · USChonnam National University · KRChina Medical University · CNSeoul National University · KRTianjin Medical University Cancer Institute and Hospital · CNKyungpook National University Medical Center · KRNanjing Medical University · CNVanderbilt University Medical Center · USCentre international de recherche sur le cancer · FRChinese Academy of Medical Sciences & Peking Union Medical College · CNFudan University · CNGuangdong Academy of Medical Sciences · CNQueen Mary Hospital · CNRIKEN Center for Integrative Medical Sciences · JPShanghai Pulmonary Hospital · CNTokyo National Hospital · JPNational Cancer Center Hospital East · JPNational University of Singapore · SG
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5MMethods for Epidemiology StudiesZIACP010181 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBERT, PAUL · 2009 to 2025
$34.8MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MTHE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MPROSTATE, LUNG, COLORECTAL, &OVARIAN CANCER SCREENINGN01CN025476 · CN · WESTAT, INC. · PI O'BRIEN, BARBARA B · 1992 to 2000
$7.9MProspective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0MShanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9MTHE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3MCancer Research UK 25514CCR NIH HHS N01 RC037004NCI NIH HHS N01 CN025404NCI NIH HHS N01 CN025476NCI NIH HHS N01 CN025511NCI NIH HHS N01 CN025512NCI NIH HHS N01 CN025514NCI NIH HHS N01 CN025515NCI NIH HHS N01 CN025516NCI NIH HHS N01 CN025522NCI NIH HHS N01 CN045165NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA080127NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA121210NCI NIH HHS R01 CA144034NCI NIH HHS R01 CA149462NCI NIH HHS R01 CA231141NCI NIH HHS R03 CA077118NCI NIH HHS R35 CA197449NCI NIH HHS R37 CA070867NCI NIH HHS U01 CA063673NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA209414NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182910NHGRI NIH HHS R01 HG010480World Health Organization 001
Abstract
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P
Indexed as
Adenocarcinoma of LungLung NeoplasmsAsia, EasternGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single Nucleotide
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07383454ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.