ArticleBMJ mental health2023
Insulin resistance, age and depression's impact on cognition in middle-aged adults from the PREVENT cohort.
Article in BMJ mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Associations of plasma biomarkers of Alzheimer's disease pathology with modifiable risk factors and cognitive and functional outcomes: evidence from cross-sectional prediction and latent path analyses in the Bio-Hermes-001 cohort.Alzheimer's research & therapy · 2026Article
- Relationships between heritable dementia risk factors, cardiovascular risk factors in young adulthood, and midlife neuropsychological outcomes.Journal of Alzheimer's disease : JAD · 2026Article
- Why do middle-aged adults use or avoid health services? A study of social and demographic determinants.Journal of preventive medicine and hygiene · 2025Article
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- Role of Peripheral and Central Insulin Resistance in Neuropsychiatric Disorders.Journal of clinical medicine · 2024Review
- The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults.The British journal of psychiatry : the journal of mental science · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlzheimer's disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health. Research has demonstrated common comorbidities among these three conditions, typically focusing on two of them at a time.
objectiveThe goal of this study, however, was to assess the inter-relationships between the three conditions, focusing on mid-life (defined as age 40-59) risk before the emergence of dementia caused by AD.
methodsIn the current study, we used cross-sectional data from 665 participants from the cohort study, PREVENT.
findingsUsing structural equation modelling, we showed that (1) insulin resistance predicts executive dysfunction in older but not younger adults in mid-life, that (2) insulin resistance predicts self-reported depression in both older and younger middle-aged adults and that (3) depression predicts deficits in visuospatial memory in older but not younger adults in mid-life.
conclusionsTogether, we demonstrate the inter-relations between three common non-communicable diseases in middle-aged adults. CLINICAL IMPLICATIONS: We emphasise the need for combined interventions and the use of resources to help adults in mid-life to modify risk factors for cognitive impairment, such as depression and diabetes.
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