ReviewThe Lancet. Neurology2023
Neuroimaging standards for research into small vessel disease-advances since 2013.
Erratum issued 4 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph
Review in The Lancet. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 715 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
715citing papers in PubMed, 6 pooled it
227.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke (SVO70)
PMID 31738483PMID 16899775PMID 18077795PMID 7678184PMID 19228842PMID 23899749PMID 26060798PMID 26501105PMID 30558400PMID 34024117other papers from this trial
Open the trial in the graphRevascularization Effect on CSVD Burden in Carotid Artery Stenosis
Dementia Risk rEgistry for Young And Middle-aged CSVD Patients in the Next 10 Years（DREAM-10）
Long-term Prognosis of Korean Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy(CADASIL) Patients: A Multicenter Prospective Study
Who cites it
715 citing papers in PubMed, 6 syntheses or guidelines pooled it, 882 citations in OpenAlex.
- Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Implications of Cranial Arterial Stenosis and Dolichoectasia for Cerebral Small-Vessel Disease Etiopathogenesis: Findings From a Prospective Mild Stroke Cohort.Circulation · 2026Pooled it
- Association between retinal microvascular pathology and lacunar infarction: a systematic review and meta-analysis.International ophthalmology · 2026Pooled it
- Stroke, Small-Vessel Disease, and Occupation: Systematic Review and Data Analysis.Journal of the American Heart Association · 2026Pooled it
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Tai Chi modulating multimodal connectivity patterns and cognitive function in cerebral small vessel disease.GeroScience · 2026Trial
- Visit-to-Visit Blood Pressure Variability and Cerebral White Matter Lesion Progression: A Pooled Individual Patient Data Analysis of 2 Trials.Neurology · 2026Trial
- Hypertension With High-Risk Features in Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Clinical Trial.JAMA neurology · 2026Trial
- Polyphenol-rich Salicornia extract in lacunar stroke: a pilot randomised trial of safety and exploratory clinical outcomes.European stroke journal · 2026Trial
- Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.GeroScience · 2026Trial
- Clustering of Cerebral Microbleeds in Cerebral Amyloid Angiopathy: A Flow Territory-Based Analysis.Journal of magnetic resonance imaging : JMRI · 2026Article
- Disease trajectory in cerebral amyloid angiopathy: a matter of time.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Article
- Metabolic Markers of MRI-Confirmed Lacunar Stroke: Observational and Mendelian Randomization Analyses.Neurology · 2026Observational
- Normative Modeling of Amygdala Subfields and Disease-Specific Vulnerabilities Across Neurological Disorders.Neuroscience bulletin · 2026Article
- Cross-phenotype and cross-species integrative genomic prioritization of FOXF2 and FOXC1 at a cerebral small vessel disease locus.Functional & integrative genomics · 2026Article
- DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study.Human brain mapping · 2026Article
- Dementia in type 2 diabetes: risk factors, disease processes and opportunities for prevention across the lifespan.Diabetologia · 2026Review
- Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.Annals of neurology · 2026Article
655 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
54 authors at 20 institutions in 19 countries.
Marco DueringInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany; Medical Image Analysis Center, University of Basel, Basel, Switzerland; Department of Biomedical Engineering, University of Basel, Basel, Switzerland. Electronic address: marco.duering@med.uni-muenchen.de.
Geert Jan BiesselsDepartment of Neurology, University Medical Center Utrecht, Utrecht, Netherlands.
Amy BrodtmannCognitive Health Initiative, Central Clinical School, Monash University, Melbourne, VIC, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Christopher ChenDepartment of Pharmacology, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Psychological Medicine, Memory Aging and Cognition Centre, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Charlotte CordonnierUniversité de Lille, INSERM, CHU Lille, U1172-Lille Neuroscience and Cognition (LilNCog), Lille, France.
Frank-Erik de LeeuwDepartment of Neurology, Donders Center for Medical Neuroscience, Radboudumc, Nijmegen, Netherlands.
Stéphanie DebetteBordeaux Population Health Research Center, University of Bordeaux, INSERM, UMR 1219, Bordeaux, France; Department of Neurology, Institute for Neurodegenerative Diseases, CHU de Bordeaux, Bordeaux, France.
Richard FrayneDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Seaman Family MR Research Centre, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada.
Eric JouventAP-HP, Lariboisière Hospital, Translational Neurovascular Centre, FHU NeuroVasc, Université Paris Cité, Paris, France; Université Paris Cité, INSERM UMR 1141, NeuroDiderot, Paris, France.
Natalia S RostDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Annemieke Ter TelgteVASCage-Research Centre on Vascular Ageing and Stroke, Innsbruck, Austria.
Rustam Al-Shahi SalmanCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Walter H BackesSchool for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, Netherlands; School for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, Netherlands; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands.
Hee-Joon BaeDepartment of Neurology, Seoul National University College of Medicine, Seoul, South Korea; Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seongn-si, South Korea.
Rosalind BrownCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Hugues ChabriatCentre Neurovasculaire Translationnel, CERVCO, INSERM U1141, FHU NeuroVasc, Université Paris Cité, Paris, France.
Alberto De LucaImage Sciences Institute, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Charles deCarliDepartment of Neurology and Center for Neuroscience, University of California, Davis, CA, USA.
Anna DewenterInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Fergus N DoubalCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Michael EwersInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Thalia S FieldDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada; Vancouver Stroke Program, Division of Neurology, University of British Columbia, Vancouver, BC, Canada.
Aravind GaneshDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada.
Steven GreenbergDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Karl G HelmerDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA; Athinoula A Martinos Center for Biomedical Imaging, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.
Saima HilalSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Angela C C JochemsCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.
Hanna JokinenDivision of Neuropsychology, HUS Neurocenter, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Hugo KuijfImage Sciences Institute, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands.
Bonnie Y K LamDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Margaret KL Cheung Research Centre for Management of Parkinsonism, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Jessica LebenbergAP-HP, Lariboisière Hospital, Translational Neurovascular Centre, FHU NeuroVasc, Université Paris Cité, Paris, France; Université Paris Cité, INSERM UMR 1141, NeuroDiderot, Paris, France.
Bradley J MacIntoshSandra E Black Centre for Brain Resilience and Repair, Hurvitz Brain Sciences, Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Computational Radiology and Artificial Intelligence Unit, Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
Pauline MaillardDepartment of Neurology and Center for Neuroscience, University of California, Davis, CA, USA.
Vincent C T MokDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Margaret KL Cheung Research Centre for Management of Parkinsonism, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China; Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
Leonardo PantoniDepartment of Biomedical and Clinical Science, University of Milan, Milan, Italy.
Salvatore RudilossoComprehensive Stroke Center, Department of Neuroscience, Hospital Clinic and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Department of Neurology, Boston University Medical Center, Boston, MA, USA; Framingham Heart Study, Framingham, MA, USA.
Markus D SchirmerDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Reinhold SchmidtDepartment of Neurology, Medical University Graz, Graz, Austria.
Colin SmithCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Julie StaalsSchool for Cardiovascular Diseases, Maastricht University Medical Center, Maastricht, Netherlands; Department of Neurology, Maastricht University Medical Center, Maastricht, Netherlands.
Michael J ThrippletonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Edinburgh Imaging and Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Susanne J van VeluwDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Prashanthi VemuriMayo Clinic, Department of Radiology, Rochester, MN, USA.
Yilong WangBeijing Tiantan Hospital, Capital Medical University, Beijing, China.
David WerringStroke Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Marialuisa ZeddeNeurology Unit, Stroke Unit, Department of Neuromotor Physiology and Rehabilitation, Azienda Unità Sanitaria-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Rufus O AkinyemiNeuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oscar H Del BruttoSchool of Medicine and Research Center, Universidad de Especialidades Espiritu Santo, Ecuador.
Hugh S MarkusStroke Research Group, Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Yi-Cheng ZhuDepartment of Neurology, Peking Union Medical College Hospital, Beijing, China.
Eric E SmithDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada; Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; German Centre for Cardiovascular Research (DZHK), Munich, Germany.
Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address: joanna.wardlaw@ed.ac.uk.
Inserm · FRMassachusetts General Hospital · USUK Dementia Research Institute · GBUniversity Medical Center Utrecht · NLUniversity of Calgary · CAUniversity of Edinburgh · GBChinese University of Hong Kong · HKLMU Klinikum · DEMaastricht University Medical Centre · NLNational University of Singapore · SGUniversity of California, Davis · USAzienda Sanitaria Unità Locale di Reggio Emilia · ITBoston University · USCapital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESGerman Center for Neurodegenerative Diseases · DEHarvard University · USMayo Clinic in Arizona · USMedical University of Graz · AT
Funding
African Neurobiobank for Precision Stroke Medicine - (ELSI) ProjectU01HG010273 · NHGRI · COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN · PI AKINYEMI, RUFUS OLUSOLA, ARULOGUN, OYEDUNNI SOLA · 2018 to 2022
$512kBritish Heart Foundation CS/18/2/33719British Heart Foundation FS/13/72/30531British Heart Foundation FS/17/53/33119British Heart Foundation PG/14/50/30891British Heart Foundation SP/12/2/29422Medical Research Council G1002605Medical Research Council G108/613Medical Research Council MR/R014140/1NHGRI NIH HHS U01 HG010273
Abstract
Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.
Indexed as
Cerebral Small Vessel DiseasesCognitive DysfunctionNeurodegenerative DiseasesActivities of Daily LivingBrainHumansMagnetic Resonance ImagingNeuroimaging
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06649240ClinicalTrials.gov
NCT06031610ClinicalTrials.gov
NCT06164262ClinicalTrials.gov
NCT07497867ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.