Evidence map›Paper›PMID 37235877›Full record

ArticleThe American journal of sports medicine2023

Histological Analysis of Regenerative Properties in Human Glenoid Labral Regions.

Le Q Hoang, Bhavya Vaish, Samira Izuagbe, Cynthia M Co, Joseph Borrelli, Peter J Millett, Liping Tang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Le Q HoangDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Bhavya VaishDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Samira IzuagbeDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Cynthia M CoDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Joseph BorrelliDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
Peter J MillettDepartment of Orthopaedic Surgery, The Steadman Clinic, Vail, Colorado, USA.ORCID 0000-0002-8298-3746
Liping TangDepartment of Bioengineering, University of Texas at Arlington, Arlington, Texas, USA.
The University of Texas at Arlington · USSteadman Clinic · US

Funding

Biomolecule releasing adhesive for cell-mediated labral repairR01AR081979 · NIAMS · UNIVERSITY OF TEXAS ARLINGTON · PI Liping Tang · 2023 to 2026
$1.6M
NIAMS NIH HHS R01 AR081979
6 · The paper itself

Abstract

backgroundThe healing capacity of the human glenoid labrum varies by tear location. Current evidence suggests that the healing capacity of meniscal and cartilage injuries relates to cellular composition and vascularity. However, little is known about the histological characteristics of the glenoid labrum and how they may affect healing potential in specific anatomic regions. HYPOTHESIS: Regenerative characteristics of the glenoid labrum differ based on the anatomic region. STUDY

designDescriptive laboratory study.

methodsHuman glenoid labra from fresh unpreserved cadavers were transversely sectioned in different anatomic regions. Masson trichrome stain was used to determine dense and loose extracellular matrix regions and vessel densities. Hematoxylin and eosin, Ki-67+, and CD90+/CD105+ stains were performed to determine total, proliferative, and progenitor cell densities, respectively. Regression models demonstrated relationships between vascular area, progenitor cell quantity, and probability of successful operation.

resultsAmong all labral aspects, the superior glenoid labrum had the highest percentage (56.8% ± 6.9%) of dense extracellular matrix or avascular tissue (

conclusionAnatomic regions of the glenoid labrum differ in extracellular matrix composition, vascularity, and cell composition. The superior glenoid labrum is deficient in vascularity and progenitor cells, which may explain the high failure rates for repairs in this location. CLINICAL RELEVANCE: Improved understanding of the composition of distinct glenoid labral positions may help to improve therapeutic strategies for labral pathology.

Indexed as

Cartilage DiseasesLacerationsShoulder JointCadaverExtracellular MatrixHumansanatomybiologic healing enhancementshoulder, generalshoulder, glenoid labrum

Identifiers

PMID37235877
PMCPMC10315864
OpenAlexW4378417223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.